Catalytic Asymmetric Electrochemical Oxidative Coupling of Tertiary Amines with Simple Ketones

• Published in: Organic letters Vol. 19; no. 8; pp. 2122 - 2125
• Main Authors: Fu, Niankai, Li, Longji, Yang, Qi, Luo, Sanzhong
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 21.04.2017; Amer Chemical Soc
• Subjects: Chemistry; Chemistry, Organic; Physical Sciences; Science & Technology; ACTIVATION; AMINATION; CROSS; STRATEGY; ARYLATION; BONDS; ALDEHYDES; C-H FUNCTIONALIZATION; BETA-KETOCARBONYLS; ANODIC-OXIDATION

Catalytic asymmetric electrochemical C–H functionalization of simple ketones has been developed. The transformation is realized by the combination of electrochemical oxidation and chiral primary amine catalysis. This metal- and oxidant-free method furnishes diverse C1-alkylated tetrahydroisoquinolin...