Cyclodimerization of Mohangamide A by Thioesterase Domain Is Directed by Substrates

• Published in: Organic letters Vol. 24; no. 24; pp. 4444 - 4448
• Main Authors: Kim, Myoun-Su, Bae, Munhyung, Song, Myoung Chong, Hwang, Sunghoon, Oh, Dong-Chan, Yoon, Yeo Joon
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 24.06.2022

Mohangamide A is a pseudo-dimeric nonribosomal peptide biosynthesized along with its monomer, WS9326A, and is expected to be formed by the head-to-tail cyclodimerization of linear WS9326A and another identical peptide chain with a different acyl side chain. In vitro experiments with the N-acetylcyst...