Photoinduced, Copper-Promoted Regio- and Stereoselective Decarboxylative Alkylation of α,β-Unsaturated Acids with Alkyl Iodides

The first example of UV light-induced, copper-catalyzed regio- and stereoselective decarboxylative coupling of α,β-unsaturated acids with alkyl iodides was reported. Under standard conditions, the 1°, 2°, and 3° alkyl iodides proceeded smoothly with the E-selective alkenes obtained in uniformly good...

Full description

Saved in:
Bibliographic Details
Published inOrganic letters Vol. 19; no. 23; pp. 6412 - 6415
Main Authors Wang, Chao, Lei, Yingjie, Guo, Mengzhun, Shang, Qinyu, Liu, Hong, Xu, Zhaoqing, Wang, Rui
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 01.12.2017
Amer Chemical Soc
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
LIGAND-FREE CONDITIONS
HALIDES
ROOM-TEMPERATURE
CINNAMIC-ACIDS
RADICAL ALKENYLATION
HECK-TYPE REACTION
CROSS-COUPLINGS
METAL-FREE
PHOTOREDOX CATALYSIS
CARBOXYLIC-ACIDS
Online AccessGet full text

Cover

More Information
Summary:The first example of UV light-induced, copper-catalyzed regio- and stereoselective decarboxylative coupling of α,β-unsaturated acids with alkyl iodides was reported. Under standard conditions, the 1°, 2°, and 3° alkyl iodides proceeded smoothly with the E-selective alkenes obtained in uniformly good yields and high stereoselectivities.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.7b03289