Identification and Biosynthesis of 1‑Mercaptoethanesulfonic Acid (1-MES), an Analogue of Coenzyme M, Found Widely in the Methanogenic Archaea

• Published in: Biochemistry (Easton) Vol. 56; no. 46; pp. 6137 - 6144
• Main Author: White, Robert H
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 21.11.2017
• Subjects: Biosynthetic Pathways; Ethylenes - metabolism; Mesna - analogs & derivatives; Mesna - metabolism; Methanococcus - enzymology; Methanococcus - growth & development; Methanococcus - metabolism; Sulfides - metabolism; Sulfonic Acids - metabolism

Here I report on the identification of 1-mercaptoethanesulfonic acid (1-MES), an analogue of 2-mercaptoethanesulfonic acid (coenzyme M, HSCoM). 1-MES and HSCoM were both present in the growth media of eight different methanogens at concentrations ranging from ∼1 to 100 μM. In an effort to determine...