Enantioselective and Diastereoselective Ir-Catalyzed Hydrogenation of α‑Substituted β‑Ketoesters via Dynamic Kinetic Resolution

• Published in: Organic letters Vol. 20; no. 7; pp. 1888 - 1892
• Main Authors: Gu, Guoxian, Lu, Jiaxiang, Yu, Ouran, Wen, Jialin, Yin, Qin, Zhang, Xumu
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 06.04.2018; Amer Chemical Soc
• Subjects: Chemistry; Chemistry, Organic; Physical Sciences; Science & Technology; KETO ESTER HYDROCHLORIDES; ASYMMETRIC TRANSFER HYDROGENATION; LIGANDS; REDUCTION; SYN-1,2-DIOL DERIVATIVES; AMIDO ESTERS; HYDROXY ESTERS; BAKERS-YEAST; AMINO ESTERS; ANTI

An iridium/f-amphol catalytic system for the enantioselective hydrogenation of α-substituted β-ketoesters via dynamic kinetic resolution is reported. The desired anti products were obtained in high yields (up to 98%) with good diastereoselectivity (up to 96:4 diastereometic ratio (dr)) and excellent...