Gold(I)-Catalyzed Synthesis of 1,5-Benzodiazepines Directly from o‑Phenylenediamines and Alkynes

A unique gold(I)-catalyzed highly atom-economic synthesis of 1,5-benzodiazepines directly from o-phenylenediamines and alkynes has been achieved for the first time.

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Bibliographic Details
Published inJournal of organic chemistry Vol. 77; no. 9; pp. 4484 - 4490
Main Authors Qian, Jianqiang, Liu, Yunkui, Cui, Jianhai, Xu, Zhenyuan
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 04.05.2012
Amer Chemical Soc
Subjects
Alkynes - chemistry
Benzodiazepines - chemical synthesis
Benzodiazepines - chemistry
Catalysis
Chemistry
Chemistry, Organic
Exact sciences and technology
Gold - chemistry
Heterocyclic compounds
Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings
Molecular Structure
Organic chemistry
Phenylenediamines - chemistry
Physical Sciences
Preparations and properties
Science & Technology
GOLD-CATALYZED HYDROAMINATION
ASSISTED SYNTHESIS
HIGHLY SELECTIVE SYNTHESIS
GOLD(III)-CATALYZED TANDEM REACTION
HETEROCYCLES
BENZODIAZEPINES
EFFICIENT
DERIVATIVES
HYDROARYLATION
CARBOCYCLES
Catalytic reaction
Acetylenic compound
Nitrogen heterocycle
Chemical synthesis
Atom economy
Alkyne
Gold I
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Summary:A unique gold(I)-catalyzed highly atom-economic synthesis of 1,5-benzodiazepines directly from o-phenylenediamines and alkynes has been achieved for the first time.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0022-3263
1520-6904
DOI:10.1021/jo300543n