Synthesis of Indazoles via N–N Bond-Forming Oxidative Cyclization from 2‑Aminomethyl-phenylamines

• Published in: Organic letters Vol. 26; no. 6; pp. 1229 - 1232
• Main Authors: Schoeggl Toledano, Anna, Bitai, Jacqueline, Covini, David, Karolyi-Oezguer, Jale, Dank, Christian, Berger, Helmut, Gollner, Andreas
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 16.02.2024; Amer Chemical Soc
• Subjects: Chemistry; Chemistry, Organic; Physical Sciences; Science & Technology; REGIOSELECTIVE SYNTHESIS; CONDENSATION; 3-COMPONENT SYNTHESIS; 2H-INDAZOLES; ONE-POT

Herein we report a method for the synthesis of indazoles from readily available 2-aminomethyl-phenylamines via N–N bond-forming oxidative cyclization. Inspired by indazole formation initially observed as a side product by N. Coskun et al. we developed a robust protocol to access indazoles in all thr...