Copper-Catalyzed Reductive Trifluoromethylation of Alkyl Iodides with Togni’s Reagent

• Published in: Organic letters Vol. 20; no. 15; pp. 4677 - 4680
• Main Authors: Chen, Yanchi, Ma, Guobin, Gong, Hegui
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 03.08.2018; Amer Chemical Soc
• Subjects: Chemistry; Chemistry, Organic; Physical Sciences; Science & Technology; CROSS-COUPLING REACTIONS; DECARBOXYLATIVE TRIFLUOROMETHYLATION; COMPLEXES; SECONDARY; ORGANIC HALIDES; FLUORINATION; ALKYLBORONIC ESTERS; ELECTROPHILES; BROMIDES; BORYLATION

This work illustrates a reductive cross-electrophile coupling protocol for trifluoromethylation of alkyl iodides under Cu-catalyzed/Ni-promoted reaction conditions. The use of diboron esters as the terminal reductant allows the effective generation of the alkyl–CF3 products with excellent functional...