IS26 Veers Genomic Plasticity and Genetic Rearrangement toward Carbapenem Hyperresistance under Sublethal Antibiotics

• Published in: mBio Vol. 13; no. 1; p. e0334021
• Main Authors: Wei, Da-Wei, Wong, Nai-Kei, Song, Yuqin, Zhang, Gang, Wang, Chao, Li, Juan, Feng, Jie
• Format: Journal Article
• Language: English
• Published: 1752 N St., N.W., Washington, DC American Society for Microbiology 08.02.2022
• Subjects: Antimicrobial Chemotherapy; antimicrobial resistance; gene amplification; genetic rearrangement; genomic plasticity; insertion sequence IS26; Klebsiella pneumoniae carbapenemase (KPC); Research Article; Klebsiella pneumoniae carbapenemase (KPC); genomic plasticity; genetic rearrangement; antimicrobial resistance; insertion sequence IS26; gene amplification

Multidrug-resistant Gram-negative carriers of Klebsiella pneumoniae carbapenemases (KPCs) often subvert antibiotic therapy due to inadequate sensitivity in laboratory detection. Although unstable gene amplification has been recognized to crucially contribute to underestimation or misestimation of an...