Thiazomycins, Thiazolyl Peptide Antibiotics from Amycolatopsis fastidiosa

• Published in: Journal of natural products (Washington, D.C.) Vol. 72; no. 5; pp. 841 - 847
• Main Authors: Zhang, Chaowei, Herath, Kithsiri, Jayasuriya, Hiranthi, Ondeyka, John G, Zink, Deborah L, Occi, James, Birdsall, Gwyneth, Venugopal, Jayashree, Ushio, Misti, Burgess, Bruce, Masurekar, Prakash, Barrett, John F, Singh, Sheo B
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society and American Society of Pharmacognosy 22.05.2009; Amer Chemical Soc; American Society of Pharmacognosy
• Subjects: Actinomycetales - chemistry; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - isolation & purification; Anti-Bacterial Agents - pharmacology; Antibiotics (antibacterial agents, antifungal agents); Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents; Applied microbiology; Biological and medical sciences; Chemistry, Medicinal; Combinatorial Chemistry Techniques; Fundamental and applied biological sciences. Psychology; Life Sciences & Biomedicine; Microbial Sensitivity Tests; Microbiology; Molecular Structure; Peptides - chemistry; Peptides - isolation & purification; Peptides - pharmacology; Peptides, Cyclic - chemistry; Peptides, Cyclic - isolation & purification; Peptides, Cyclic - pharmacology; Pharmacology & Pharmacy; Plant Sciences; Science & Technology; Stereoisomerism; Thiazoles - chemistry; Thiazoles - isolation & purification; Thiazoles - pharmacology; NOCATHIACIN-I ANALOGS; GLYCOTHIOHEXIDE-ALPHA; DEHYDROALANINE; SEBEKIA SP; ANTIBACTERIAL ACTIVITY; CONVERSION; BIOSYNTHESIS; PLATENSIMYCIN; INHIBITOR; FABF; Peptides; Thiazole derivatives; Amycolatopsis; Biosynthesis; Pseudonocardiaceae; Biological activity; Macrocycle; Antibiotic; Microbial origin; Bacteria; Isolation; Actinomycetes; Antibacterial agent; Structural analysis

Thiazolyl peptides are a class of highly rigid trimacrocyclic compounds consisting of varying but large numbers of thiazole rings. The need for new antibacterial agents to treat infections caused by resistant bacteria prompted a reinvestigation of this class, leading to the previous isolation of thi...