Sinuscalide A: An Antiviral Norcembranoid with an 8/8-Fused Carbon Scaffold from the South China Sea Soft Coral Sinularia scabra

• Published in: Journal of organic chemistry Vol. 87; no. 15; pp. 9806 - 9814
• Main Authors: Liu, Jing, Tang, Qi, Huang, Jian, Li, Te, Ouyang, Han, Lin, Wen-han, Yan, Xiao-jun, Yan, Xia, He, Shan
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 05.08.2022; Amer Chemical Soc
• Subjects: antiviral properties; bioassays; biochemical pathways; bone formation; carbon; Chemistry; Chemistry, Organic; circular dichroism spectroscopy; corals; diterpenoids; Human enterovirus; organic chemistry; Physical Sciences; Salmonella; Science & Technology; Sinularia; South China Sea; spectral analysis; Streptococcus pneumoniae; X-ray diffraction; South China Sea; NORDITERPENOIDS; DITERPENOIDS; NATURAL-PRODUCTS; GENUS

Sinuscalide A (1), featuring an uncommon 8/8-fused carbon scaffold, three new norditerpenes, sinuscalides B–D (2–4), and sinuscatone A (5), with a 5/4/9 tricyclic carbon ring system, along with four known compounds were isolated from the South China Sea soft coral Sinularia scabra. The structures of...