Photolabile Linkers for Solid-Phase Synthesis

• Published in: ACS combinatorial science Vol. 20; no. 7; pp. 377 - 399
• Main Authors: Mikkelsen, Remi J. T, Grier, Katja E, Mortensen, Kim T, Nielsen, Thomas E, Qvortrup, Katrine
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 09.07.2018
• Subjects: Amines - chemistry; Benzoin - analogs & derivatives; Benzoin - chemistry; Indicators and Reagents - chemistry; Light; Nitrobenzenes - chemistry; Oxidation-Reduction; Photolysis; Solid-Phase Synthesis Techniques - methods; photolabile linker; combinatorial chemistry; chemical biology; solid-phase synthesis

Photolabile linkers are the subjects of intense research because they allow the release of the target molecule simply by irradiation. Photochemical release of synthesis products is often facilitated without additional reagents under mild reaction conditions, which may even be environmentally friendl...