Rationally Designed Peptides and Peptidomimetics as Inhibitors of Amyloid‑β (Aβ) Aggregation: Potential Therapeutics of Alzheimer’s Disease

• Published in: ACS combinatorial science Vol. 19; no. 2; pp. 55 - 80
• Main Authors: Goyal, Deepti, Shuaib, Suniba, Mann, Sukhmani, Goyal, Bhupesh
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 13.02.2017
• Subjects: Alzheimer Disease - drug therapy; Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Amino Acid Sequence; Amyloid beta-Peptides - antagonists & inhibitors; Amyloid beta-Peptides - chemistry; Amyloid beta-Peptides - metabolism; Animals; Drug Design; Humans; Models, Molecular; Peptides - chemistry; Peptides - pharmacology; Peptidomimetics - chemistry; Peptidomimetics - pharmacology; Protein Aggregates - drug effects; peptide inhibitors; peptidomimetics; Alzheimer’s disease (AD); amyloid aggregation; amyloid-β (Aβ) peptide

Alzheimer’s disease (AD) is a progressive neurodegenerative disease with no clinically accepted treatment to cure or halt its progression. The worldwide effort to develop peptide-based inhibitors of amyloid-β (Aβ) aggregation can be considered an unplanned combinatorial experiment. An understanding...