Strong Hydration Ability of Silk Fibroin Suppresses Formation and Recrystallization of Ice Crystals During Cryopreservation

• Published in: Biomacromolecules Vol. 23; no. 2; pp. 478 - 486
• Main Authors: Fan, Qingrui, Dou, Mengjia, Mao, Junqiang, Hou, Yi, Liu, Shuo, Zhao, Lishan, Lv, Jianyong, Liu, Zhang, Wang, Yilin, Rao, Wei, Jin, Shenglin, Wang, Jianjun
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 14.02.2022
• Subjects: Cell Survival; Cryopreservation; Cryoprotective Agents - chemistry; Cryoprotective Agents - pharmacology; Fibroins; Humans; Ice

The cryopreservation (CP) of cell/tissue is indispensable in medical science. However, the formation of ice during cooling and ice recrystallization/growth in time of thawing present significant risk of cell/tissue damage upon analysis of CP process. Herein, the natural and biocompatible silk fibroi...