A Library of Elastin-like Proteins with Tunable Matrix Ligands for In Vitro 3D Neural Cell Culture

• Published in: Biomacromolecules Vol. 24; no. 12; pp. 5926 - 5939
• Main Authors: Suhar, Riley A., Huang, Michelle S., Navarro, Renato S., Aviles Rodriguez, Giselle, Heilshorn, Sarah C.
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 11.12.2023
• Subjects: Animals; Cell Culture Techniques - methods; Elastin - chemistry; Extracellular Matrix - chemistry; Hydrogels - chemistry; Ligands; Peptides - chemistry

Hydrogels with encapsulated cells have widespread biomedical applications, both as tissue-mimetic 3D cultures in vitro and as tissue-engineered therapies in vivo. Within these hydrogels, the presentation of cell-instructive extracellular matrix (ECM)-derived ligands and matrix stiffness are critical...