Epidermal Microfluidic Electrochemical Detection System: Enhanced Sweat Sampling and Metabolite Detection

• Published in: ACS sensors Vol. 2; no. 12; pp. 1860 - 1868
• Main Authors: Martín, Aida, Kim, Jayoung, Kurniawan, Jonas F, Sempionatto, Juliane R, Moreto, Jose R, Tang, Guangda, Campbell, Alan S, Shin, Andrew, Lee, Min Yul, Liu, Xiaofeng, Wang, Joseph
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 22.12.2017
• Subjects: Biosensing Techniques - instrumentation; Biosensing Techniques - methods; Dimethylpolysiloxanes - chemistry; Electrochemical Techniques - instrumentation; Electrochemical Techniques - methods; Enzymes, Immobilized - chemistry; Epidermis - metabolism; Glucose - analysis; Glucose Oxidase - chemistry; Humans; Lab-On-A-Chip Devices; Lactic Acid - analysis; Limit of Detection; Microfluidic Analytical Techniques - instrumentation; Microfluidic Analytical Techniques - methods; Mixed Function Oxygenases - chemistry; Monitoring, Physiologic - instrumentation; Monitoring, Physiologic - methods; Sweat - chemistry; glucose; microfluidic device; flexible electronics; electrochemical detection; wearable sensors; metabolite monitoring; lactate; sweat sampling

Despite tremendous recent efforts, noninvasive sweat monitoring is still far from delivering its early analytical promise. Here, we describe a flexible epidermal microfluidic detection platform fabricated through hybridization of lithographic and screen-printed technologies, for efficient and fast s...