Enabling Sensitive Phenotypic Profiling of Cancer-Derived Small Extracellular Vesicles Using Surface-Enhanced Raman Spectroscopy Nanotags

• Published in: ACS sensors Vol. 5; no. 3; pp. 764 - 771
• Main Authors: Zhang, Wei, Jiang, Lianmei, Diefenbach, Russell J, Campbell, Douglas H, Walsh, Bradley J, Packer, Nicolle H, Wang, Yuling
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 27.03.2020
• Subjects: Biomarkers, Tumor; Cell Line, Tumor; Extracellular Vesicles; Humans; Nanostructures; Neoplasms; Phenotype; Spectrum Analysis, Raman; phenotype; SERS nanotags; multiplex detection; extracellular vesicles; immunoassay

Circulating cancer-derived small extracellular vesicles (EVs) are nanoscale membranous vesicles shed from cancer cells that are released into surrounding body fluids. Small EVs contain biomolecules associated with cancer such as DNA and proteins for cell-to-cell communication. Therefore, small EVs h...