Drug Discovery with DNA-Encoded Chemical Libraries

• Published in: Bioconjugate chemistry Vol. 21; no. 9; pp. 1571 - 1580
• Main Authors: Buller, Fabian, Mannocci, Luca, Scheuermann, Jörg, Neri, Dario
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 15.09.2010
• Subjects: Binding sites; Deoxyribonucleic acid; DNA; DNA - analysis; DNA - chemistry; DNA - genetics; Drug Discovery; Experiments; Gene Library; Molecules; Polypeptides; Small Molecule Libraries - chemistry; Small Molecule Libraries - pharmacology

DNA-encoded chemical libraries represent a novel avenue for the facile discovery of small molecule ligands against target proteins of biological or pharmaceutical importance. Library members consist of small molecules covalently attached to unique DNA fragments that serve as amplifiable identificati...