Recent Advancements in the Design of Nanodelivery Systems of siRNA for Cancer Therapy

• Published in: Molecular pharmaceutics Vol. 19; no. 12; pp. 4506 - 4526
• Main Authors: Yadav, Dokkari Nagalaxmi, Ali, Mohammad Sadik, Thanekar, Ajinkya Madhukar, Pogu, Sunil Venkanna, Rengan, Aravind Kumar
• Format: Journal Article
• Language: English
• Published: American Chemical Society 05.12.2022
• Subjects: siRNA delivery; RNAi; cancer; therapy; nanocarriers

RNA interference (RNAi) has increased the possibility of restoring RNA drug targets for cancer treatment. Small interfering RNA (siRNA) is a promising therapeutic RNAi tool that targets the defective gene by inhibiting its mRNA expression and stopping its translation. However, siRNAs have flaws like...