XA pH-Responsive and Colitis-Targeted Nanoparticle Loaded with Shikonin for the Oral Treatment of Inflammatory Bowel Disease in Mice

• Published in: Molecular pharmaceutics Vol. 19; no. 11; pp. 4157 - 4170
• Main Authors: Feng, Juewen, Wang, Yanbing, Lv, Yingni, Fang, Siqi, Ren, Mengjiao, Yao, Min, Lan, Minbo, Zhao, Yuzheng, Gao, Feng
• Format: Journal Article
• Language: English
• Published: American Chemical Society 07.11.2022
• Subjects: pH-sensitive; nanoparticle; oral; colitis-targeted; inflammatory bowel disease; shikonin

Epidemiology shows that more than 6.8 million people in the world are influenced by inflammatory bowel disease (IBD) each year. IBD is a refractory inflammatory disease, and the disease mainly affects the colon. Shikonin (SK) was originally extracted from traditional Chinese medicine “Zicao” (with a...