In Situ Reaction Monitoring Reveals a Diastereoselective Ligand Exchange Reaction between the Intrinsically Chiral Au38(SR)24 and Chiral Thiols

• Published in: Journal of the American Chemical Society Vol. 134; no. 50; pp. 20302 - 20305
• Main Authors: Knoppe, Stefan, Azoulay, Raymond, Dass, Amala, Bürgi, Thomas
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 19.12.2012
• Subjects: enantiomers; gold; high performance liquid chromatography; ligands; monitoring; nanomaterials; thiols

The ligand exchange reaction between racemic Au38(2-PET)24 (2-PET = 2-phenylethylthiolate) clusters and enantiopure 1,1′-binaphthyl-2,2′-dithiol (BINAS) was monitored in situ using a chiral high-performance liquid chromatography approach. In the first exchange step, a clear preference of R-BINAS for...