An Efficient Rh/O2 Catalytic System for Oxidative C–H Activation/Annulation: Evidence for Rh(I) to Rh(III) Oxidation by Molecular Oxygen

• Published in: Journal of the American Chemical Society Vol. 135; no. 24; pp. 8850 - 8853
• Main Authors: Zhang, Guoying, Yang, Lei, Wang, Yanyu, Xie, Yinjun, Huang, Hanmin
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 19.06.2013; Amer Chemical Soc
• Subjects: Chemistry; Chemistry, Multidisciplinary; oxidation; oxygen; Physical Sciences; salts; Science & Technology; FUNCTIONALIZATION; ACTIVATION; COUPLING REACTIONS; RHODIUM(III)-CATALYZED SYNTHESIS; TERTIARY-AMINES; RH; BOND FORMATION; INTERNAL ALKYNES; ISOQUINOLINIUM SALTS; BENZOIC-ACIDS

A novel and efficient Rh/O2 catalytic system has been developed and shown to catalyze highly efficient oxidative C–H activation/annulation reactions, producing a broad range of isoquinolinium salts with high turnover numbers (up to 740). Mechanistic studies provided strong evidence of facile oxidati...