Biodegradability of Disulfide-Organosilica Nanoparticles Evaluated by Soft X‑ray Photoelectron Spectroscopy: Cancer Therapy Implications

• Published in: ACS applied nano materials Vol. 2; no. 1; pp. 479 - 488
• Main Authors: Mekaru, Harutaka, Yoshigoe, Akitaka, Nakamura, Michihiro, Doura, Tomohiro, Tamanoi, Fuyuhiko
• Format: Journal Article
• Language: English
• Published: American Chemical Society 25.01.2019
• Subjects: biodegradability; nanoparticles; glutathione; Raman spectroscopy; (3-mercaptopropyl)methyldimethoxysilane; X-ray photoelectron spectroscopy; (3-mercaptopropyl)trimethoxysilane

Two kinds of organosilica nanoparticles (NPs) that were fabricated from thiol-containing precursors, (3-mercaptopropyl)­trimethoxysilane (MPMS) and (3-mercaptopropyl)­methyldimethoxysilane (MPDMS), are potential delivery vehicles of anticancer drugs. MPMS can form three siloxane bonds, but MPDMS for...