Establishment of replication-competent vesicular stomatitis virus recapitulating SADS-CoV entry

• Published in: Journal of virology Vol. 98; no. 5; p. e0195723
• Main Authors: Zhu, Zihui, Han, Yutong, Gong, Mingli, Sun, Bo, Zhang, Rong, Ding, Qiang
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 14.05.2024
• Subjects: Alphacoronavirus - genetics; Angiotensin-Converting Enzyme 2 - genetics; Angiotensin-Converting Enzyme 2 - metabolism; Animals; Antibodies, Neutralizing - immunology; Antibodies, Viral - immunology; Cell Line; Chlorocebus aethiops; Coronavirus Infections - prevention & control; Coronavirus Infections - virology; HEK293 Cells; Humans; Mice; Rabbits; Serine Endopeptidases - genetics; Serine Endopeptidases - immunology; Serine Endopeptidases - metabolism; Spike Glycoprotein, Coronavirus - genetics; Spike Glycoprotein, Coronavirus - immunology; Spike Glycoprotein, Coronavirus - metabolism; Swine; Vero Cells; Vesicular stomatitis Indiana virus - genetics; Vesiculovirus - genetics; Viral Vaccines - genetics; Viral Vaccines - immunology; Virology; Virus Internalization; Virus Replication; Virus-Cell Interactions; VSV; viral entry; VSV-vectored vaccine; SADS-CoV; replication-competent

Zoonotic coronaviruses pose a continuous threat to human health, with newly identified bat-borne viruses like swine acute diarrhea syndrome coronavirus (SADS-CoV) causing high mortality in piglets. studies indicate that SADS-CoV can infect cell lines from diverse species, including humans, highlight...