Development of Nanoscale Oil Bodies for Targeted Treatment of Lung Cancer

• Published in: Journal of agricultural and food chemistry Vol. 66; no. 36; pp. 9438 - 9445
• Main Authors: Chiang, Chung-Jen, Lin, Li-Jen, Wu, Chia-Pei, Chen, Chih-Jung, Chao, Yun-Peng
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 12.09.2018
• Subjects: Animals; Antineoplastic Agents, Phytogenic - administration & dosage; Antineoplastic Agents, Phytogenic - chemistry; Camptothecin - administration & dosage; Camptothecin - chemistry; Drug Compounding; Female; Humans; Lung Neoplasms - drug therapy; Lung Neoplasms - genetics; Lung Neoplasms - metabolism; Mice; Mice, Inbred BALB C; Molecular Targeted Therapy; Nanostructures - administration & dosage; Nanostructures - chemistry; Plant Oils - chemistry; Receptor, Epidermal Growth Factor - antagonists & inhibitors; Receptor, Epidermal Growth Factor - genetics; Receptor, Epidermal Growth Factor - metabolism; lung cancer; nanoscale oil bodies; camptothecin; epidermal growth factor receptor

Lung cancer is the most widespread disease and is frequently associated with a high level of epidermal growth factor receptor (EGFR). This study was thus conducted to provide a proof-of-concept approach for targeted therapy of lung cancer by development of nanoscale oil bodies (NOBs). This was carri...