Further New Gypenosides from Jiaogulan (Gynostemma pentaphyllum)

• Published in: Journal of agricultural and food chemistry Vol. 65; no. 29; pp. 5926 - 5934
• Main Authors: Wang, Jun, Yang, Jun-Li, Zhou, Pan-Pan, Meng, Xian-Hua, Shi, Yan-Ping
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 26.07.2017; Amer Chemical Soc
• Subjects: Agriculture; Agriculture, Multidisciplinary; Cell Line, Tumor; Cell Survival - drug effects; Chemistry; Chemistry, Applied; Enzyme Inhibitors - chemistry; Enzyme Inhibitors - isolation & purification; Enzyme Inhibitors - pharmacology; Food Science & Technology; Gynostemma - chemistry; Humans; Life Sciences & Biomedicine; Molecular Structure; Physical Sciences; Plant Extracts - chemistry; Plant Extracts - isolation & purification; Plant Extracts - pharmacology; Plant Leaves - chemistry; Protein Tyrosine Phosphatase, Non-Receptor Type 1 - antagonists & inhibitors; Protein Tyrosine Phosphatase, Non-Receptor Type 1 - metabolism; Science & Technology; Gynostemma pentaphyllum; jiaogulan; PTP1B inhibitory activity; cytotoxicity; new gypenosides; OLEANANE TRITERPENES; CELLS; DAMMARANE-TYPE GLYCOSIDES; SAPONINS; CAMELLIA-JAPONICA; MAKINO

Jiaogulan (Gynostemma pentaphyllum) has been widely used as a herbal tea, dietary supplement, and vegetable in Asian countries. In this study, six new gypenosides (1–6) were isolated from the aerial parts of G. pentaphyllum. Their molecular structures were elucidated through spectroscopic analysis a...