Exploiting Natural Maltol for Synthesis of Novel Hydroxypyridone Derivatives as Promising Anti-Virulence Agents in Bactericides Discovery

• Published in: Journal of agricultural and food chemistry Vol. 71; no. 17; pp. 6603 - 6616
• Main Authors: Xiao, Wan-Lin, Wang, Na, Yang, Lin-Li, Feng, Yu-Mei, Chu, Pan-Long, Zhang, Jiao-Jiao, Liu, Shuai-Shuai, Shao, Wu-Bin, Zhou, Xiang, Liu, Li-Wei, Yang, Song
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 03.05.2023; Amer Chemical Soc
• Subjects: Agricultural and Environmental Chemistry; Agriculture; Agriculture, Multidisciplinary; Anti-Bacterial Agents - pharmacology; Chemistry; Chemistry, Applied; Food Science & Technology; Life Sciences & Biomedicine; Microbial Sensitivity Tests; Oryza - microbiology; Pesticides - pharmacology; Physical Sciences; Plant Diseases - microbiology; Science & Technology; Virulence Factors - genetics; Xanthomonas; antibacterial activity; 3-hydroxy-2-methyl-1-pyridin-4-(1H)-one derivatives; bacterial virulence factors; pesticide discovery; PROTEIN; MODE; BIOFILM; INDUCTION; XANTHOMONAS-ORYZAE; PATHOGENICITY; ORYZAE PV. ORYZAE; GENE; MOTILITY

Anti-infection strategies based on suppression of bacterial virulence factors represent a crucial direction for the development of new antibacterial agents to address the resistance triggered by traditional drugs’/pesticides’ bactericidal activity. To identify and obtain more effective and diverse m...