Casein Hydrolysate with Glycemic Control Properties: Evidence from Cells, Animal Models, and Humans

• Published in: Journal of agricultural and food chemistry Vol. 66; no. 17; pp. 4352 - 4363
• Main Authors: Drummond, Elaine, Flynn, Sarah, Whelan, Helena, Nongonierma, Alice B, Holton, Thérèse A, Robinson, Aisling, Egan, Thelma, Cagney, Gerard, Shields, Denis C, Gibney, Eileen R, Newsholme, Philip, Gaudel, Celine, Jacquier, Jean-Christophe, Noronha, Nessa, FitzGerald, Richard J, Brennan, Lorraine
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 02.05.2018
• Subjects: 3T3-L1 Cells; Adult; Aged; Animals; Blood Glucose - analysis; Blood Glucose - drug effects; Caseins - administration & dosage; Cell Line; Dietary Supplements; Female; Humans; Insulin - metabolism; Insulin Secretion; Insulin-Secreting Cells; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Middle Aged; Models, Animal; Obesity; Overweight; Postprandial Period; casein; hydrolysate; nutrition; insulin; postprandial glycemia

Evidence exists to support the role of dairy derived proteins whey and casein in glycemic management. The objective of the present study was to use a cell screening method to identify a suitable casein hydrolysate and to examine its ability to impact glycemia related parameters in an animal model an...