Casein Hydrolysate with Glycemic Control Properties: Evidence from Cells, Animal Models, and Humans

Evidence exists to support the role of dairy derived proteins whey and casein in glycemic management. The objective of the present study was to use a cell screening method to identify a suitable casein hydrolysate and to examine its ability to impact glycemia related parameters in an animal model an...

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Published inJournal of agricultural and food chemistry Vol. 66; no. 17; pp. 4352 - 4363
Main Authors Drummond, Elaine, Flynn, Sarah, Whelan, Helena, Nongonierma, Alice B, Holton, Thérèse A, Robinson, Aisling, Egan, Thelma, Cagney, Gerard, Shields, Denis C, Gibney, Eileen R, Newsholme, Philip, Gaudel, Celine, Jacquier, Jean-Christophe, Noronha, Nessa, FitzGerald, Richard J, Brennan, Lorraine
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LanguageEnglish
Published United States American Chemical Society 02.05.2018
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Abstract Evidence exists to support the role of dairy derived proteins whey and casein in glycemic management. The objective of the present study was to use a cell screening method to identify a suitable casein hydrolysate and to examine its ability to impact glycemia related parameters in an animal model and in humans. Following screening for the ability to stimulate insulin secretion in pancreatic beta cells, a casein hydrolysate was selected and further studied in the ob/ob mouse model. An acute postprandial study was performed in 62 overweight and obese adults. Acute and long-term supplementation with the casein hydrolysate in in vivo studies in mice revealed a glucose lowering effect and a lipid reducing effect of the hydrolysate (43% reduction in overall liver fat). The postprandial human study revealed a significant increase in insulin secretion (p = 0.04) concomitant with a reduction in glucose (p = 0.03). The area under the curve for the change in glucose decreased from 181.84 ± 14.6 to 153.87 ± 13.02 (p = 0.009). Overall, the data supports further work on the hydrolysate to develop into a functional food product.
AbstractList Evidence exists to support the role of dairy derived proteins whey and casein in glycemic management. The objective of the present study was to use a cell screening method to identify a suitable casein hydrolysate and to examine its ability to impact glycemia related parameters in an animal model and in humans. Following screening for the ability to stimulate insulin secretion in pancreatic beta cells, a casein hydrolysate was selected and further studied in the ob/ob mouse model. An acute postprandial study was performed in 62 overweight and obese adults. Acute and long-term supplementation with the casein hydrolysate in in vivo studies in mice revealed a glucose lowering effect and a lipid reducing effect of the hydrolysate (43% reduction in overall liver fat). The postprandial human study revealed a significant increase in insulin secretion (p = 0.04) concomitant with a reduction in glucose (p = 0.03). The area under the curve for the change in glucose decreased from 181.84 ± 14.6 to 153.87 ± 13.02 (p = 0.009). Overall, the data supports further work on the hydrolysate to develop into a functional food product.
Author Gibney, Eileen R
Whelan, Helena
Gaudel, Celine
Cagney, Gerard
Robinson, Aisling
Nongonierma, Alice B
FitzGerald, Richard J
Brennan, Lorraine
Egan, Thelma
Holton, Thérèse A
Drummond, Elaine
Noronha, Nessa
Jacquier, Jean-Christophe
Newsholme, Philip
Shields, Denis C
Flynn, Sarah
AuthorAffiliation University of Limerick
School of Biomolecular and Biomedical Sciences, Food for Health Ireland (FHI) and UCD Conway Institute of Biomolecular and Biomedical Research
Department of Biological Sciences
School of Agriculture and Food Science, Institute of Food and Health and Food for Health Ireland (FHI)
School of Medicine, Food for Health Ireland (FHI) and UCD Conway Institute of Biomolecular and Biomedical Research
Food for Health Ireland (FHI)
AuthorAffiliation_xml – name:
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– name: School of Medicine, Food for Health Ireland (FHI) and UCD Conway Institute of Biomolecular and Biomedical Research
– name: School of Agriculture and Food Science, Institute of Food and Health and Food for Health Ireland (FHI)
– name: Food for Health Ireland (FHI)
– name: School of Biomolecular and Biomedical Sciences, Food for Health Ireland (FHI) and UCD Conway Institute of Biomolecular and Biomedical Research
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hydrolysate
nutrition
insulin
postprandial glycemia
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Snippet Evidence exists to support the role of dairy derived proteins whey and casein in glycemic management. The objective of the present study was to use a cell...
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SubjectTerms 3T3-L1 Cells
Adult
Aged
Animals
Blood Glucose - analysis
Blood Glucose - drug effects
Caseins - administration & dosage
Cell Line
Dietary Supplements
Female
Humans
Insulin - metabolism
Insulin Secretion
Insulin-Secreting Cells
Male
Mice
Mice, Inbred C57BL
Mice, Obese
Middle Aged
Models, Animal
Obesity
Overweight
Postprandial Period
Title Casein Hydrolysate with Glycemic Control Properties: Evidence from Cells, Animal Models, and Humans
URI http://dx.doi.org/10.1021/acs.jafc.7b05550
https://www.ncbi.nlm.nih.gov/pubmed/29638124
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