Novel Biomedical Functions of Surfactin A from Bacillus subtilis in Wound Healing Promotion and Scar Inhibition

• Published in: Journal of agricultural and food chemistry Vol. 68; no. 26; pp. 6987 - 6997
• Main Authors: Yan, Lu, Liu, Guanwen, Zhao, Bin, Pang, Bing, Wu, Wanqin, Ai, Chongyang, Zhao, Xixi, Wang, Xinglong, Jiang, Chunmei, Shao, Dongyan, Liu, Qianlong, Li, Meixuan, Wang, Lei, Shi, Junling
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 01.07.2020
• Subjects: Animals; Bacillus subtilis - chemistry; Bacillus subtilis - metabolism; Bioactive Constituents, Metabolites, and Functions; Cicatrix - drug therapy; Cicatrix - genetics; Cicatrix - metabolism; Cicatrix - physiopathology; Humans; Hypoxia-Inducible Factor 1, alpha Subunit - genetics; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; Lipopeptides - metabolism; Lipopeptides - pharmacology; Male; Mice; NF-kappa B - genetics; NF-kappa B - metabolism; Transforming Growth Factor beta - metabolism; Vascular Endothelial Growth Factor A - genetics; Vascular Endothelial Growth Factor A - metabolism; Wound Healing - drug effects; cell migration; wound healing; surfactin A; Bacillus subtilis; scar inhibition

Surfactin produced by Bacillus subtilis is a powerful biosurfactant in food, cosmetics, and pesticide industries. However, its suitability in wound healing applications is uncertain. In this article, we determined the effects of surfactin A from B. subtilis on wound healing, angiogenesis, cell migra...