Kaempferol Reverses Aerobic Glycolysis via miR-339-5p-Mediated PKM Alternative Splicing in Colon Cancer Cells

• Published in: Journal of agricultural and food chemistry Vol. 69; no. 10; pp. 3060 - 3068
• Main Authors: Wu, Haili, Cui, Mimi, Li, Chenglu, Li, Hanqing, Dai, Yuhao, Cui, Kaili, Li, Zhuoyu
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 17.03.2021
• Subjects: Alternative Splicing; Bioactive Constituents, Metabolites, and Functions; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms - drug therapy; Colonic Neoplasms - genetics; Glycolysis; Heterogeneous-Nuclear Ribonucleoproteins - metabolism; Humans; Kaempferols - pharmacology; MicroRNAs - genetics; MicroRNAs - metabolism; Polypyrimidine Tract-Binding Protein - metabolism; miR-339-5p; hnRNPA1/PTBP1; kaempferol; PKM2; aerobic glycolysis

Colon cancer is an aggressive malignancy with very limited therapeutic approaches. The available therapeutic agents for colon cancer show strong adverse effects and poor effectiveness, indicating the urgent need to identify new therapeutic drugs for this malignancy. Kaempferol, a flavonoid found in...