Regulation of DNA Repair Fidelity by Molecular Checkpoints:  “Gates” in DNA Polymerase β's Substrate Selection

• Published in: Biochemistry (Easton) Vol. 45; no. 51; pp. 15142 - 15156
• Main Authors: Radhakrishnan, Ravi, Arora, Karunesh, Wang, Yanli, Beard, William A, Wilson, Samuel H, Schlick, Tamar
• Format: Journal Article
• Language: English
• Published: American Chemical Society 26.12.2006

With an increasing number of structural, kinetic, and modeling studies of diverse DNA polymerases in various contexts, a complex dynamical view of how atomic motions might define molecular “gates” or checkpoints that contribute to polymerase specificity and efficiency is emerging. Such atomic-level...