Nanostructured Organosilica Nitric Oxide Donors Intrinsically Regulate Macrophage Polarization with Antitumor Effect

• Published in: ACS nano Vol. 16; no. 7; pp. 10943 - 10957
• Main Authors: Theivendran, Shevanuja, Gu, Zhengying, Tang, Jie, Yang, Yannan, Song, Hao, Yang, Yang, Zhang, Min, Cheng, Dan, Yu, Chengzhong
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 26.07.2022
• Subjects: Humans; Macrophage Activation; Macrophages; Nanoparticles; Neoplasms; Nitric Oxide; Nitric Oxide Donors - pharmacology; Silicon Dioxide - pharmacology; macrophage; nitric oxide; organosilica; nanoparticles; immunotherapy

Nitric oxide (NO) has many important biological functions; however, it has been a long-standing challenge to utilize the exogenous NO donor itself in the activation of macrophages for cancer immunotherapy. Herein, we report the synthesis of a nanoparticle-based NO delivery platform with a rational d...