Enabling Metallophotoredox Catalysis in Parallel Solution-Phase Synthesis Using Disintegrating Reagent Tablets

Compressed tablets containing a mixture of a photocatalyst, a nickel catalyst, an inorganic base, and an inert excipient are employed as a fast, safe, and user-friendly chemical delivery system for two different metallophotoredox-catalyzed reactions. This delivery method simplifies the preparation o...

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Published inJournal of organic chemistry Vol. 86; no. 23; pp. 16535 - 16547
Main Authors Borlinghaus, Niginia, Schönfeld, Barbara, Heitz, Stephanie, Klee, Johanna, Vukelić, Stella, Braje, Wilfried M, Jolit, Anais
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 03.12.2021
Subjects
Catalysis
Indicators and Reagents
Solubility
Tablets
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Abstract Compressed tablets containing a mixture of a photocatalyst, a nickel catalyst, an inorganic base, and an inert excipient are employed as a fast, safe, and user-friendly chemical delivery system for two different metallophotoredox-catalyzed reactions. This delivery method simplifies the preparation of compound libraries using photoredox chemistry in a parallel setting. The reagent tablets were successfully applied to late-stage functionalization of drug-like intermediates. These tablets can be prepared with various reagents and catalysts in different sizes and be stored on the bench thanks to blister packaging.
AbstractList Compressed tablets containing a mixture of a photocatalyst, a nickel catalyst, an inorganic base, and an inert excipient are employed as a fast, safe, and user-friendly chemical delivery system for two different metallophotoredox-catalyzed reactions. This delivery method simplifies the preparation of compound libraries using photoredox chemistry in a parallel setting. The reagent tablets were successfully applied to late-stage functionalization of drug-like intermediates. These tablets can be prepared with various reagents and catalysts in different sizes and be stored on the bench thanks to blister packaging.
Author Klee, Johanna
Braje, Wilfried M
Jolit, Anais
Vukelić, Stella
Heitz, Stephanie
Borlinghaus, Niginia
Schönfeld, Barbara
AuthorAffiliation Medicinal Chemistry Department, Neuroscience Discovery Research
AbbVie Deutschland GmbH & Co. KG
NCE Formulation Sciences
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Solubility
Tablets
Title Enabling Metallophotoredox Catalysis in Parallel Solution-Phase Synthesis Using Disintegrating Reagent Tablets
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