Perfluorotributylamine-Loaded Albumin Nanoparticles Downregulate Platelet-Derived TGFβ to Inhibit Tumor Metastasis

• Published in: ACS nano Vol. 17; no. 16; pp. 15388 - 15400
• Main Authors: Luo, Lifeng, Zhang, Baoli, Tao, Feng, Chen, Zhong, Ye, Qingsong, Zhao, Xiaozhi, Wu, Jinhui
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 22.08.2023
• Subjects: TGFβ; platelet; tumor metastasis; human serum albumin; perfluorotributylamine

Tumor metastasis contributes to the low overall survival of tumor patients, while transforming growth factor-β (TGFβ) has been recognized as a prominently promoting factor in the development of tumor metastasis. Platelets reserve abundant TGFβ, which will be secreted to peripheral blood after activa...