Glucose-Responsive Nanoparticles for Rapid and Extended Self-Regulated Insulin Delivery

• Published in: ACS nano Vol. 14; no. 1; pp. 488 - 497
• Main Authors: Volpatti, Lisa R, Matranga, Morgan A, Cortinas, Abel B, Delcassian, Derfogail, Daniel, Kevin B, Langer, Robert, Anderson, Daniel G
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 28.01.2020
• Subjects: Animals; Cell Line; Dextrans - chemical synthesis; Dextrans - chemistry; Dextrans - metabolism; Drug Delivery Systems; Glucose - chemistry; Glucose - metabolism; Humans; Insulin - blood; Insulin - chemistry; Insulin - metabolism; Mice; Nanoparticles - chemistry; Particle Size; Surface Properties; nanoparticles; biomaterials; drug delivery; insulin; stimuli-responsive; diabetes

To mimic native insulin activity, materials have been developed that encapsulate insulin, glucose oxidase, and catalase for glucose-responsive insulin delivery. A major challenge, however, has been achieving the desired kinetics of both rapid and extended release. Here, we tune insulin release profi...