Extravasating Neutrophils Open Vascular Barrier and Improve Liposomes Delivery to Tumors

• Published in: ACS nano Vol. 13; no. 11; pp. 12599 - 12612
• Main Authors: Naumenko, Victor A, Vlasova, Kseniya Yu, Garanina, Anastasiia S, Melnikov, Pavel A, Potashnikova, Daria M, Vishnevskiy, Daniil A, Vodopyanov, Stepan S, Chekhonin, Vladimir P, Abakumov, Maxim A, Majouga, Alexander G
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 26.11.2019
• Subjects: extravasation; intravital microscopy; tumor microenvironment; liposomes; neutrophil

Liposomes are the most extensively used nanocarriers in cancer therapy. Despite the advantages these vehicles provide over free drugs, there are still limitations with regards to the efficiency of liposomes delivery to tumors and off-target accumulation. A better understanding of nanodrugs extravasa...