Determining the Time Window for Dynamic Nanowire Cell Penetration Processes

• Published in: ACS nano Vol. 9; no. 12; pp. 11667 - 11677
• Main Authors: Xie, Xi, Aalipour, Amin, Gupta, Sneha V, Melosh, Nicholas A
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 22.12.2015
• Subjects: Animals; Cell Adhesion - physiology; Cell Membrane - physiology; Cell Membrane - ultrastructure; CHO Cells; Cricetulus; Microscopy, Electron, Scanning; Nanowires - chemistry; traction force; nanowire array; cell membrane penetration; cell adhesion; nanowire delivery

Nanowire (NW) arrays offer opportunities for parallel, nondestructive intracellular access for biomolecule delivery, intracellular recording, and sensing. Spontaneous cell membrane penetration by vertical nanowires is essential for these applications, yet the time- and geometry-dependent penetration...