The Potential of Eight Plasma Proteins as Biomarkers in Redefining Leptospirosis Diagnosis

• Published in: Journal of proteome research Vol. 23; no. 9; pp. 4027 - 4042
• Main Authors: Fish-Low, Cheng-Yee, Than, Leslie Thian Lung, Ling, King-Hwa, Sekawi, Zamberi
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 06.09.2024
• Subjects: Acute-Phase Proteins - analysis; Adult; amyloid; apolipoprotein A-II; biomarkers; Biomarkers - blood; Blood Proteins - analysis; blood serum; C-reactive protein; C-Reactive Protein - analysis; Carrier Proteins - blood; Case-Control Studies; chemokine CXCL4; dengue; Dengue - blood; Dengue - diagnosis; diagnostic techniques; endemic diseases; family; Female; gene expression regulation; Glycoproteins; Humans; leptospirosis; Leptospirosis - blood; Leptospirosis - diagnosis; Malaysia; Male; Membrane Glycoproteins - blood; Membrane Proteins - blood; Middle Aged; mortality; Platelet Factor 4 - blood; profilins; proteome; Proteome - analysis; Proteomics - methods; seroconversion; Serum Amyloid A Protein - analysis; spectroscopy; Thrombospondin 1 - blood; Malaysia; iTRAQ; leptospirosis; biomarker; plasma proteome

Leptospirosis, a notifiable endemic disease in Malaysia, has higher mortality rates than regional dengue fever. Diverse clinical symptoms and limited diagnostic methods complicate leptospirosis diagnosis. The demand for accurate biomarker-based diagnostics is increasing. This study investigated the...