Identification of Early Stage Liver Fibrosis by Modifications in the Interstitial Space Diffusive Microenvironment Using Fluorescent Single-Walled Carbon Nanotubes

• Published in: Nano letters Vol. 24; no. 18; pp. 5603 - 5609
• Main Authors: Lee, Antony, Simon, Apolline A., Boyreau, Adeline, Allain-Courtois, Nathalie, Lambert, Benjamin, Pradère, Jean-Philippe, Saltel, Frédéric, Cognet, Laurent
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 08.05.2024
• Subjects: Animals; Chemical Sciences; Diffusion; Disease Models, Animal; Extracellular Matrix - metabolism; Fluorescent Dyes - chemistry; Liver - pathology; Liver Cirrhosis - pathology; Material chemistry; Mice; Nanotubes, Carbon - chemistry; liver fibrosis; diffusion; interstitial space; single-particle tracking; carbon nanotube fluorescence; tissue nanostructure; Tissue nanostructure; Single-particle tracking; Liver fibrosis; Diffusion; Carbon nanotube fluorescence; Interstitial space

During liver fibrosis, recurrent hepatic injuries lead to the accumulation of collagen and other extracellular matrix components in the interstitial space, ultimately disrupting liver functions. Early stages of liver fibrosis may be reversible, but opportunities for diagnosis at these stages are cur...