Dual-Peptide-Functionalized Nanofibrous Scaffolds Recruit Host Endothelial Progenitor Cells for Vasculogenesis to Repair Calvarial Defects

• Published in: ACS applied materials & interfaces Vol. 12; no. 3; pp. 3474 - 3493
• Main Authors: Li, Li, Liu, Wanqian, Zhao, Yulan, Ma, Pingping, Zha, Shenfang, Chen, Peixin, Lu, Hongwei, Jiang, Xiaorui, Wan, Shuang, Luo, Jiangming, Dai, Qijie, Hu, Junxian, Utomo, Yohanes Kristo Sugiarto, Han, Xinyun, Yang, Zhengwei, Yang, Li, He, Qingyi
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 22.01.2020
• Subjects: Animals; Bone Diseases - physiopathology; Bone Diseases - therapy; Bone Regeneration; Cell Adhesion; Cell Proliferation; Endothelial Progenitor Cells - cytology; Endothelial Progenitor Cells - transplantation; Humans; Male; Nanofibers - chemistry; Neovascularization, Pathologic; Peptides - administration & dosage; Peptides - chemistry; Rats; Rats, Sprague-Dawley; Skull - abnormalities; Skull - blood supply; Skull - surgery; Tissue Engineering; Tissue Scaffolds - chemistry; cell recruitment; peptides; bone regeneration; vascularization; nanofibrous scaffolds; endothelial progenitor cells

Vasculogenesis (de novo formation of vessels) induced by endothelial progenitor cells (EPCs) is requisite for vascularized bone regeneration. However, there exist few available options for promoting vasculogenesis within artificial bone grafts except for exogenous EPC transplantation, which suffers...