A Type of Atypical AIEgen Used for One-Photon/Two-Photon Targeted Imaging in Live Cells

• Published in: ACS applied bio materials Vol. 3; no. 1; pp. 505 - 511
• Main Authors: Sun, Kai, Zhang, Yin-Li, Chen, Xiao-Lan, Su, Hui-Fang, Peng, Qiu-Chen, Yu, Bing, Qu, Ling-Bo, Li, Kai
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 21.01.2020
• Subjects: aggregation-induced emission; lipid droplets; lysosome; indolo[1,2-a]quinoline; one-photon/two-photon imaging
• ISSN: 2576-6422; 2576-6422
• DOI: 10.1021/acsabm.9b00946

Aggregation-induced emission luminogens (AIEgens) with a large electron donor and acceptor (D–A) conjugated system have been widely used in the development of organic light emitting diodes (OLEDs), chemosensors, and bioimaging materials due to their excellent properties such as high quantum yields, long emission wavelengths, controllable luminescence lifetimes, and nonlinear optics (NLO) properties. However, most of the AIE materials have been derived from limited classic AIE cores such as tetraphenylethene (TPE) and tetraphenylpyrazine (TPP), and thus, tedious syntheses or later modifications toward those AIEgens have always been unavoidable. In this report, a type of atypical AIEgens (designated as ASIQs) composed of large conjugated structures with a natural electron D–A system is disclosed, which shows large Stokes shifts, high photostabilities, excellent cell permeabilities, low biotoxicities, and good two-photon excited capacities, making them suitable for applications of one-photon/two-photon targeted imaging in live cells. In short, this work offers a type of atypical AIEgens which will possibly become an ideal platform leading to more structurally diverse and functionally excellent AIE-based luminescent materials.