Drug-Eluting, Bioresorbable Cardiovascular StentsChallenges and Perspectives

Globally, the leading causes of natural death are attributed to coronary heart disease and type 1 and type 2 diabetes. High blood pressure levels, high cholesterol levels, smoking, and poor eating habits lead to the agglomeration of plaque in the arteries, reducing the blood flow. The implantation o...

Full description

Saved in:
Bibliographic Details
Published inACS applied bio materials Vol. 5; no. 10; pp. 4701 - 4717
Main Authors Vallejo-Zamora, Julio A., Vega-Cantu, Yadira I., Rodriguez, Ciro, Cordell, Geoffrey A., Rodriguez-Garcia, Aida
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 17.10.2022
Subjects
bioresorbable cardiovascular stents
everolimus
drug-eluting stents
metallic alloys
liposomes
nanocarriers
magnesium
drug delivery
bare-metal stents
Online AccessGet full text

Cover

Abstract Globally, the leading causes of natural death are attributed to coronary heart disease and type 1 and type 2 diabetes. High blood pressure levels, high cholesterol levels, smoking, and poor eating habits lead to the agglomeration of plaque in the arteries, reducing the blood flow. The implantation of devices used to unclog vessels, known as stents, sometimes results in a lack of irrigation due to the excessive proliferation of endothelial tissue within the blood vessels and is known as restenosis. The use of drug-eluting stents (DESs) to deliver antiproliferative drugs has led to the development of different encapsulation techniques. However, due to the potency of the drugs used in the initial stent designs, a chronic inflammatory reaction of the arterial wall known as thrombosis can cause a myocardial infarction (MI). One of the most promising drugs to reduce this risk is everolimus, which can be encapsulated in lipid systems for controlled release directly into the artery. This review aims to discuss the current status of stent design, fabrication, and functionalization. Variables such as the mechanical properties, metals and their alloys, drug encapsulation and controlled elution, and stent degradation are also addressed. Additionally, this review covers the use of polymeric surface coatings on stents and the recent advances in layer-by-layer coating and drug delivery. The advances in nanoencapsulation techniques such as liposomes and micro- and nanoemulsions and their functionalization in bioresorbable, drug-eluting stents are also highlighted.
AbstractList Globally, the leading causes of natural death are attributed to coronary heart disease and type 1 and type 2 diabetes. High blood pressure levels, high cholesterol levels, smoking, and poor eating habits lead to the agglomeration of plaque in the arteries, reducing the blood flow. The implantation of devices used to unclog vessels, known as stents, sometimes results in a lack of irrigation due to the excessive proliferation of endothelial tissue within the blood vessels and is known as restenosis. The use of drug-eluting stents (DESs) to deliver antiproliferative drugs has led to the development of different encapsulation techniques. However, due to the potency of the drugs used in the initial stent designs, a chronic inflammatory reaction of the arterial wall known as thrombosis can cause a myocardial infarction (MI). One of the most promising drugs to reduce this risk is everolimus, which can be encapsulated in lipid systems for controlled release directly into the artery. This review aims to discuss the current status of stent design, fabrication, and functionalization. Variables such as the mechanical properties, metals and their alloys, drug encapsulation and controlled elution, and stent degradation are also addressed. Additionally, this review covers the use of polymeric surface coatings on stents and the recent advances in layer-by-layer coating and drug delivery. The advances in nanoencapsulation techniques such as liposomes and micro- and nanoemulsions and their functionalization in bioresorbable, drug-eluting stents are also highlighted.
Author Vega-Cantu, Yadira I.
Rodriguez-Garcia, Aida
Rodriguez, Ciro
Cordell, Geoffrey A.
Vallejo-Zamora, Julio A.
AuthorAffiliation Natural Products, Inc
Facultad de Ciencias Biológicas, Instituto de Biotecnología, Ciudad Universitaria
University of Florida
College of Pharmacy
Laboratorio Nacional de Manufactura Aditiva y Digital (MADIT)
AuthorAffiliation_xml – name: Natural Products, Inc
– name: College of Pharmacy
– name: Laboratorio Nacional de Manufactura Aditiva y Digital (MADIT)
– name: Facultad de Ciencias Biológicas, Instituto de Biotecnología, Ciudad Universitaria
– name: University of Florida
Author_xml – sequence: 1
  givenname: Julio A.
  surname: Vallejo-Zamora
  fullname: Vallejo-Zamora, Julio A.
– sequence: 2
  givenname: Yadira I.
  surname: Vega-Cantu
  fullname: Vega-Cantu, Yadira I.
– sequence: 3
  givenname: Ciro
  surname: Rodriguez
  fullname: Rodriguez, Ciro
  organization: Laboratorio Nacional de Manufactura Aditiva y Digital (MADIT)
– sequence: 4
  givenname: Geoffrey A.
  orcidid: 0000-0003-2536-3097
  surname: Cordell
  fullname: Cordell, Geoffrey A.
  organization: University of Florida
– sequence: 5
  givenname: Aida
  orcidid: 0000-0002-0299-4753
  surname: Rodriguez-Garcia
  fullname: Rodriguez-Garcia, Aida
  email: aida.rodriguezgrc@uanl.edu.mx, aidrod@hotmail.com
  organization: Facultad de Ciencias Biológicas, Instituto de Biotecnología, Ciudad Universitaria
BackLink https://www.ncbi.nlm.nih.gov/pubmed/36150217$$D View this record in MEDLINE/PubMed
BookMark eNp1kEtOwzAQQC1URAt0yxJliRAp_sSxvYRQPlKlIgHryEkmJZUbFzupxEm4CqfiDKRKQWxYzSzePGneIRrUtgaETgieEEzJpc69zlYTmmPMOdlDI8pFHMYRpYM_-xCNvV9ijCnGjEh1gIYsJrwTiBGa37h2EU5N21T14iK4rqwDb12mMwNBol1R2Y32eWu0C54aqBv_9fGZvGpjoF6AD3RdBI_g_BryptqAP0b7pTYexrt5hF5up8_JfTib3z0kV7NQM4absJBacUWiAgSOBI5LpiPGY0WzUskyikRMVSkLITUmTEY54xwLwUEWqihlGbMjdNZ7186-teCbdFX5HIzRNdjWp1QQEUtF6Rad9GjurPcOynTtqpV27ynB6bZj2ndMdx27g9Odu81WUPziP9U64LwHusN0aVtXd6_-Z_sG-Qx_Eg
CitedBy_id crossref_primary_10_1016_j_mtbio_2024_101133
crossref_primary_10_1002_admt_202400210
crossref_primary_10_1038_s41598_023_49367_9
Cites_doi 10.1016/j.bioactmat.2020.04.016
10.1016/j.actbio.2019.08.042
10.1016/j.jjcc.2019.07.016
10.1016/S0140-6736(18)32467-X
10.1016/j.jallcom.2018.07.206
10.1016/j.jconrel.2019.06.025
10.1080/17434440.2020.1736037
10.3389/fbioe.2021.705886
10.4161/21592527.2014.959874
10.1016/j.jcin.2020.04.021
10.1016/j.cis.2020.102197
10.1016/0005-2736(79)90085-3
10.1002/adfm.202005361
10.1016/j.matdes.2017.10.045
10.1016/j.porgcoat.2017.09.008
10.1016/j.amjcard.2019.06.021
10.3390/met9020186
10.1016/j.mtla.2020.100727
10.1016/j.cis.2019.07.006
10.1016/j.ijpharm.2017.05.005
10.1016/j.addr.2006.01.016
10.3109/08982109509010233
10.1016/j.mtcomm.2019.100777
10.1161/CIRCULATIONAHA.118.034456
10.1016/j.msec.2008.12.019
10.1016/j.jtemb.2018.10.003
10.1016/j.amjcard.2019.06.014
10.1016/j.jcin.2017.07.033
10.1016/j.jcin.2009.10.002
10.1016/j.jcin.2020.03.053
10.15420/ecr.2018:8:2
10.1016/j.colsurfb.2014.09.029
10.1016/j.msec.2018.08.049
10.1016/j.procir.2020.05.149
10.1007/s11837-020-04085-9
10.1007/s10439-019-02346-6
10.1097/00007890-199707150-00008
10.1016/0005-2787(76)90527-X
10.1016/j.jcin.2017.02.029
10.1007/s44164-022-00009-w
10.1155/2021/6652648
10.1248/bpb.35.975
10.1016/j.matlet.2010.10.068
10.1186/1556-276X-8-102
10.1002/anie.201703763
10.4028/www.scientific.net/MSF.987.77
10.15171/bi.2018.08
10.7164/antibiotics.28.721
10.3390/ma14123381
10.1016/j.jddst.2021.102446
10.7150/ntno.62730
10.1016/j.jacc.2010.06.007
10.1016/j.hlc.2021.06.513
10.1016/j.polymer.2021.124080
10.1016/B978-0-12-813740-6.00005-3
10.1016/j.carrev.2019.05.023
10.1134/S2075113320020161
10.1016/j.ijpharm.2019.04.023
10.1016/j.surfcoat.2021.126972
10.1016/j.jacc.2020.11.010
10.1002/ccd.28387
10.1016/j.amepre.2015.06.011
10.1016/B978-0-08-100496-8.00001-9
10.1016/j.jcin.2018.11.040
10.1136/openhrt-2017-000680
10.1007/s12928-020-00734-7
10.4103/1735-5362.213979
10.1016/j.nano.2021.102387
10.5772/60009
10.3389/fcvm.2020.589571
10.1007/s10237-021-01514-9
10.1016/j.carrev.2020.12.025
10.1109/MEMS46641.2020.9056379
10.1007/978-94-017-7515-1_25
10.1590/S1677-54492008000300010
10.1155/2020/5462949
10.1093/eurheartj/ehw196
10.1080/13543776.2020.1720649
10.1016/j.matdes.2013.06.055
10.1016/j.tifs.2020.12.003
10.1016/j.colsurfb.2019.04.018
10.1016/j.biomaterials.2019.119641
10.1007/978-1-4614-9164-4_3
10.1016/j.ijpharm.2020.120051
10.1016/j.jbiomech.2020.109841
10.1080/17434440.2019.1649133
10.3390/ijms22062792
10.1016/j.jma.2021.07.019
10.1080/08982100600848579
10.1016/j.ijpharm.2012.10.029
10.1016/j.jacc.2015.04.017
10.4068/cmj.2018.54.1.55
10.5339/gcsp.2015.63
10.3390/pharmaceutics12040349
10.1016/j.watres.2019.06.036
10.29252/jcc.2.2.5
10.1016/j.jacc.2006.03.042
10.1021/ma0717136
10.1016/j.compscitech.2021.109194
10.1155/2019/1310792
10.1016/j.actbio.2021.01.031
10.1016/j.jcin.2019.04.054
10.1016/j.jconrel.2020.09.008
10.3346/jkms.2021.36.e259
10.1038/s41467-020-16945-8
10.1016/j.matpr.2019.06.570
10.1007/s10534-020-00244-2
10.1002/jbm.b.34790
10.1007/s00253-013-4852-7
10.1111/j.1755-5922.2010.00187.x
10.3390/polym13020292
10.3390/ma13245633
10.1016/S0167-7799(00)89017-4
10.3934/matersci.2018.4.559
10.1007/s41745-021-00276-8
10.1161/CIRCULATIONAHA.110.971606
10.1016/j.colsurfa.2020.124555
10.1016/j.ahj.2019.02.017
10.1002/ccd.23397
10.21037/jtd.2017.06.34
10.3390/polym13081221
10.1021/ma202270w
10.1016/j.surfcoat.2021.127508
10.1016/j.jvs.2012.12.069
10.1111/aor.13851
10.1007/s12928-016-0420-2
10.1016/j.carrev.2018.11.006
10.3390/molecules23040907
10.1016/j.msec.2019.109950
10.1016/j.ejpb.2019.12.017
10.2147/IJN.S204221
10.1158/1078-0432.CCR-19-2697
10.1016/B978-0-12-817870-6.00004-3
10.1016/S0142-9612(02)00233-8
10.1016/j.bioactmat.2021.09.002
10.1016/j.jvs.2008.10.016
10.1155/2012/608593
10.1016/j.ejpb.2020.12.005
10.1007/978-3-319-45444-3_22
10.1039/C8RA08541B
10.2494/photopolymer.32.511
10.1002/anie.201709934
10.1016/j.polymdegradstab.2020.109254
10.1021/la9905113
10.1016/B978-0-08-100496-8.00007-X
10.1161/CIRCINTERVENTIONS.110.959882
10.1016/j.ijcard.2014.09.143
10.15171/apb.2017.002
10.1016/j.ijpharm.2013.07.003
10.1016/j.msec.2014.12.049
10.2165/00003088-200443020-00002
10.5603/CJ.2017.0089
10.1067/mcp.2001.112969
10.1023/A:1008939400812
10.1016/j.ihj.2016.10.008
10.1002/jbm.b.31922
10.1016/j.carrev.2018.04.022
10.1016/S0140-6736(20)30925-9
10.1016/S0002-9149(99)00484-1
10.1063/5.0037298
10.1002/adhm.201501019
10.1023/A:1006808119862
10.1016/j.jcin.2017.06.070
10.3390/app9173527
10.1002/app.50389
10.1016/j.actbio.2009.10.006
10.1016/S0041-1345(98)00588-0
10.1080/136457002760273340
10.1021/ie102163z
10.1002/advs.201900856
10.1080/17434440.2020.1747434
10.1021/acsami.0c01444
10.1021/acs.biomac.0c01082
10.3390/app11041478
10.6515/ACS20151013G
ContentType Journal Article
Copyright 2022 American Chemical Society
Copyright_xml – notice: 2022 American Chemical Society
DBID NPM
AAYXX
CITATION
7X8
DOI 10.1021/acsabm.2c00551
DatabaseName PubMed
CrossRef
MEDLINE - Academic
DatabaseTitle PubMed
CrossRef
MEDLINE - Academic
DatabaseTitleList
MEDLINE - Academic
PubMed
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Engineering
EISSN 2576-6422
EndPage 4717
ExternalDocumentID 10_1021_acsabm_2c00551
36150217
b363643040
Genre Journal Article
Review
GroupedDBID ABFRP
ABUCX
ACS
AHGAQ
ALMA_UNASSIGNED_HOLDINGS
EBS
GGK
VF5
VG9
53G
ABQRX
BAANH
CUPRZ
NPM
AAYXX
CITATION
7X8
ID FETCH-LOGICAL-a330t-d8a95914de704706f3a435692bf98f447629f8d78a01384c3550775e8d9df8f63
IEDL.DBID ACS
ISSN 2576-6422
IngestDate Fri Aug 16 08:22:34 EDT 2024
Fri Aug 23 01:46:47 EDT 2024
Tue Oct 15 08:50:36 EDT 2024
Wed Oct 19 03:12:40 EDT 2022
IsPeerReviewed true
IsScholarly true
Issue 10
Keywords bioresorbable cardiovascular stents
everolimus
drug-eluting stents
metallic alloys
liposomes
nanocarriers
magnesium
drug delivery
bare-metal stents
Language English
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-a330t-d8a95914de704706f3a435692bf98f447629f8d78a01384c3550775e8d9df8f63
Notes ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ORCID 0000-0003-2536-3097
0000-0002-0299-4753
PMID 36150217
PQID 2717689226
PQPubID 23479
PageCount 17
ParticipantIDs proquest_miscellaneous_2717689226
crossref_primary_10_1021_acsabm_2c00551
pubmed_primary_36150217
acs_journals_10_1021_acsabm_2c00551
PublicationCentury 2000
PublicationDate 2022-10-17
PublicationDateYYYYMMDD 2022-10-17
PublicationDate_xml – month: 10
  year: 2022
  text: 2022-10-17
  day: 17
PublicationDecade 2020
PublicationPlace United States
PublicationPlace_xml – name: United States
PublicationTitle ACS applied bio materials
PublicationTitleAlternate ACS Appl. Bio Mater
PublicationYear 2022
Publisher American Chemical Society
Publisher_xml – name: American Chemical Society
References ref45/cit45
ref99/cit99
ref3/cit3
ref81/cit81
ref16/cit16
ref52/cit52
ref114/cit114
ref23/cit23
ref115/cit115
ref116/cit116
ref110/cit110
ref111/cit111
ref2/cit2
ref112/cit112
ref113/cit113
ref71/cit71
ref117/cit117
ref20/cit20
ref48/cit48
ref118/cit118
ref74/cit74
ref119/cit119
ref10/cit10
ref35/cit35
ref89/cit89
ref19/cit19
ref93/cit93
ref42/cit42
ref96/cit96
ref107/cit107
ref120/cit120
ref178/cit178
ref109/cit109
ref13/cit13
ref122/cit122
ref105/cit105
ref61/cit61
ref176/cit176
ref67/cit67
ref38/cit38
ref128/cit128
ref90/cit90
ref124/cit124
ref64/cit64
ref126/cit126
ref54/cit54
ref6/cit6
ref18/cit18
ref136/cit136
ref137/cit137
ref65/cit65
Vavale S. D. (ref166/cit166) 2018; 6
ref171/cit171
ref97/cit97
ref101/cit101
ref11/cit11
ref102/cit102
ref29/cit29
ref174/cit174
ref76/cit76
ref86/cit86
ref170/cit170
ref32/cit32
ref39/cit39
ref168/cit168
ref5/cit5
ref43/cit43
ref80/cit80
ref133/cit133
ref28/cit28
ref132/cit132
ref91/cit91
ref148/cit148
ref55/cit55
ref144/cit144
ref12/cit12
ref167/cit167
ref163/cit163
ref66/cit66
Kalra J. (ref130/cit130) 2013
ref179/cit179
ref22/cit22
ref121/cit121
ref175/cit175
ref33/cit33
ref87/cit87
ref106/cit106
Aboofazeli R. (ref150/cit150) 2010; 9
ref140/cit140
ref129/cit129
ref44/cit44
ref70/cit70
ref98/cit98
ref125/cit125
ref9/cit9
ref152/cit152
ref153/cit153
ref154/cit154
ref27/cit27
ref63/cit63
ref151/cit151
ref56/cit56
ref159/cit159
ref92/cit92
ref155/cit155
ref156/cit156
ref157/cit157
ref158/cit158
ref8/cit8
ref59/cit59
ref85/cit85
ref34/cit34
ref37/cit37
ref60/cit60
ref88/cit88
ref17/cit17
ref82/cit82
ref147/cit147
ref160/cit160
ref143/cit143
ref53/cit53
ref145/cit145
ref21/cit21
ref149/cit149
ref162/cit162
ref46/cit46
ref164/cit164
ref49/cit49
ref75/cit75
ref24/cit24
ref141/cit141
ref50/cit50
ref78/cit78
ref36/cit36
ref83/cit83
ref138/cit138
ref79/cit79
ref139/cit139
ref100/cit100
ref172/cit172
ref25/cit25
ref173/cit173
ref103/cit103
ref72/cit72
ref14/cit14
Rodriguez C. A. (ref31/cit31) 2018
ref57/cit57
Wilson W. M. (ref77/cit77) 2013; 4
ref169/cit169
ref51/cit51
ref134/cit134
ref135/cit135
ref40/cit40
ref68/cit68
ref94/cit94
ref131/cit131
ref146/cit146
ref26/cit26
ref161/cit161
ref142/cit142
ref73/cit73
ref69/cit69
ref165/cit165
ref15/cit15
ref62/cit62
ref41/cit41
ref58/cit58
ref95/cit95
ref108/cit108
ref104/cit104
ref177/cit177
ref4/cit4
ref30/cit30
ref47/cit47
ref84/cit84
ref127/cit127
ref1/cit1
ref123/cit123
ref7/cit7
References_xml – ident: ref162/cit162
  doi: 10.1016/j.bioactmat.2020.04.016
– ident: ref7/cit7
  doi: 10.1016/j.actbio.2019.08.042
– ident: ref47/cit47
  doi: 10.1016/j.jjcc.2019.07.016
– ident: ref79/cit79
  doi: 10.1016/S0140-6736(18)32467-X
– ident: ref88/cit88
  doi: 10.1016/j.jallcom.2018.07.206
– ident: ref139/cit139
  doi: 10.1016/j.jconrel.2019.06.025
– ident: ref54/cit54
  doi: 10.1080/17434440.2020.1736037
– ident: ref140/cit140
  doi: 10.3389/fbioe.2021.705886
– ident: ref86/cit86
  doi: 10.4161/21592527.2014.959874
– ident: ref12/cit12
  doi: 10.1016/j.jcin.2020.04.021
– ident: ref165/cit165
  doi: 10.1016/j.cis.2020.102197
– ident: ref135/cit135
  doi: 10.1016/0005-2736(79)90085-3
– ident: ref136/cit136
– ident: ref17/cit17
  doi: 10.1002/adfm.202005361
– ident: ref67/cit67
  doi: 10.1016/j.matdes.2017.10.045
– ident: ref146/cit146
  doi: 10.1016/j.porgcoat.2017.09.008
– ident: ref29/cit29
  doi: 10.1016/j.amjcard.2019.06.021
– ident: ref92/cit92
  doi: 10.3390/met9020186
– ident: ref95/cit95
  doi: 10.1016/j.mtla.2020.100727
– ident: ref126/cit126
  doi: 10.1016/j.cis.2019.07.006
– ident: ref148/cit148
  doi: 10.1016/j.ijpharm.2017.05.005
– ident: ref6/cit6
  doi: 10.1016/j.addr.2006.01.016
– ident: ref131/cit131
  doi: 10.3109/08982109509010233
– ident: ref175/cit175
  doi: 10.1016/j.mtcomm.2019.100777
– ident: ref66/cit66
  doi: 10.1161/CIRCULATIONAHA.118.034456
– ident: ref83/cit83
  doi: 10.1016/j.msec.2008.12.019
– ident: ref109/cit109
  doi: 10.1016/j.jtemb.2018.10.003
– ident: ref14/cit14
  doi: 10.1016/j.amjcard.2019.06.014
– ident: ref78/cit78
  doi: 10.1016/j.jcin.2017.07.033
– ident: ref56/cit56
  doi: 10.1016/j.jcin.2009.10.002
– ident: ref57/cit57
  doi: 10.1016/j.jcin.2020.03.053
– ident: ref72/cit72
  doi: 10.15420/ecr.2018:8:2
– ident: ref137/cit137
  doi: 10.1016/j.colsurfb.2014.09.029
– ident: ref171/cit171
  doi: 10.1016/j.msec.2018.08.049
– volume: 4
  start-page: 85
  year: 2013
  ident: ref77/cit77
  publication-title: Res. Rep. Clin. Cardiol.
  contributor:
    fullname: Wilson W. M.
– ident: ref172/cit172
  doi: 10.1016/j.procir.2020.05.149
– ident: ref91/cit91
  doi: 10.1007/s11837-020-04085-9
– ident: ref167/cit167
  doi: 10.1007/s10439-019-02346-6
– ident: ref61/cit61
  doi: 10.1097/00007890-199707150-00008
– ident: ref132/cit132
  doi: 10.1016/0005-2787(76)90527-X
– ident: ref38/cit38
  doi: 10.1016/j.jcin.2017.02.029
– ident: ref11/cit11
  doi: 10.1007/s44164-022-00009-w
– ident: ref106/cit106
  doi: 10.1155/2021/6652648
– ident: ref145/cit145
  doi: 10.1248/bpb.35.975
– ident: ref96/cit96
  doi: 10.1016/j.matlet.2010.10.068
– ident: ref127/cit127
  doi: 10.1186/1556-276X-8-102
– ident: ref118/cit118
  doi: 10.1002/anie.201703763
– ident: ref119/cit119
  doi: 10.4028/www.scientific.net/MSF.987.77
– ident: ref153/cit153
  doi: 10.15171/bi.2018.08
– ident: ref62/cit62
  doi: 10.7164/antibiotics.28.721
– ident: ref98/cit98
  doi: 10.3390/ma14123381
– ident: ref161/cit161
  doi: 10.1016/j.jddst.2021.102446
– ident: ref154/cit154
  doi: 10.7150/ntno.62730
– volume: 6
  start-page: 126
  year: 2018
  ident: ref166/cit166
  publication-title: Int. J. Innovative Knowl. Concepts
  contributor:
    fullname: Vavale S. D.
– ident: ref18/cit18
  doi: 10.1016/j.jacc.2010.06.007
– ident: ref27/cit27
  doi: 10.1016/j.hlc.2021.06.513
– ident: ref124/cit124
  doi: 10.1016/j.polymer.2021.124080
– ident: ref102/cit102
  doi: 10.1016/B978-0-12-813740-6.00005-3
– ident: ref50/cit50
  doi: 10.1016/j.carrev.2019.05.023
– ident: ref94/cit94
  doi: 10.1134/S2075113320020161
– ident: ref160/cit160
  doi: 10.1016/j.ijpharm.2019.04.023
– ident: ref169/cit169
  doi: 10.1016/j.surfcoat.2021.126972
– ident: ref2/cit2
  doi: 10.1016/j.jacc.2020.11.010
– ident: ref58/cit58
  doi: 10.1002/ccd.28387
– ident: ref3/cit3
  doi: 10.1016/j.amepre.2015.06.011
– ident: ref4/cit4
  doi: 10.1016/B978-0-08-100496-8.00001-9
– ident: ref40/cit40
  doi: 10.1016/j.jcin.2018.11.040
– ident: ref30/cit30
  doi: 10.1136/openhrt-2017-000680
– ident: ref19/cit19
  doi: 10.1007/s12928-020-00734-7
– ident: ref142/cit142
  doi: 10.4103/1735-5362.213979
– ident: ref9/cit9
  doi: 10.1016/j.nano.2021.102387
– ident: ref164/cit164
  doi: 10.5772/60009
– ident: ref76/cit76
  doi: 10.3389/fcvm.2020.589571
– ident: ref113/cit113
  doi: 10.1007/s10237-021-01514-9
– ident: ref26/cit26
  doi: 10.1016/j.carrev.2020.12.025
– ident: ref116/cit116
  doi: 10.1109/MEMS46641.2020.9056379
– ident: ref73/cit73
  doi: 10.1007/978-94-017-7515-1_25
– ident: ref89/cit89
  doi: 10.1590/S1677-54492008000300010
– ident: ref13/cit13
  doi: 10.1155/2020/5462949
– ident: ref101/cit101
  doi: 10.1093/eurheartj/ehw196
– ident: ref152/cit152
  doi: 10.1080/13543776.2020.1720649
– ident: ref104/cit104
  doi: 10.1016/j.matdes.2013.06.055
– ident: ref129/cit129
  doi: 10.1016/j.tifs.2020.12.003
– ident: ref10/cit10
  doi: 10.1016/j.colsurfb.2019.04.018
– ident: ref24/cit24
  doi: 10.1016/j.biomaterials.2019.119641
– start-page: 27
  volume-title: Fundamentals of Pharmaceutical Nanoscience.
  year: 2013
  ident: ref130/cit130
  doi: 10.1007/978-1-4614-9164-4_3
  contributor:
    fullname: Kalra J.
– ident: ref138/cit138
  doi: 10.1016/j.ijpharm.2020.120051
– ident: ref32/cit32
  doi: 10.1016/j.jbiomech.2020.109841
– ident: ref100/cit100
  doi: 10.1080/17434440.2019.1649133
– ident: ref159/cit159
  doi: 10.3390/ijms22062792
– ident: ref179/cit179
  doi: 10.1016/j.jma.2021.07.019
– ident: ref143/cit143
  doi: 10.1080/08982100600848579
– ident: ref16/cit16
  doi: 10.1016/j.ijpharm.2012.10.029
– ident: ref8/cit8
  doi: 10.1016/j.jacc.2015.04.017
– ident: ref53/cit53
  doi: 10.4068/cmj.2018.54.1.55
– ident: ref90/cit90
  doi: 10.5339/gcsp.2015.63
– ident: ref97/cit97
  doi: 10.3390/pharmaceutics12040349
– ident: ref99/cit99
  doi: 10.1016/j.watres.2019.06.036
– ident: ref115/cit115
  doi: 10.29252/jcc.2.2.5
– ident: ref41/cit41
  doi: 10.1016/j.jacc.2006.03.042
– ident: ref170/cit170
  doi: 10.1021/ma0717136
– ident: ref69/cit69
  doi: 10.1016/j.compscitech.2021.109194
– ident: ref110/cit110
  doi: 10.1155/2019/1310792
– ident: ref81/cit81
  doi: 10.1016/j.actbio.2021.01.031
– ident: ref25/cit25
  doi: 10.1016/j.jcin.2019.04.054
– ident: ref15/cit15
  doi: 10.1016/j.jconrel.2020.09.008
– ident: ref176/cit176
  doi: 10.3346/jkms.2021.36.e259
– ident: ref121/cit121
  doi: 10.1038/s41467-020-16945-8
– ident: ref103/cit103
  doi: 10.1016/j.matpr.2019.06.570
– volume: 9
  start-page: 325
  year: 2010
  ident: ref150/cit150
  publication-title: Iran. J. Pharm. Res.
  contributor:
    fullname: Aboofazeli R.
– ident: ref93/cit93
  doi: 10.1007/s10534-020-00244-2
– ident: ref105/cit105
  doi: 10.1002/jbm.b.34790
– ident: ref59/cit59
  doi: 10.1007/s00253-013-4852-7
– ident: ref151/cit151
  doi: 10.1111/j.1755-5922.2010.00187.x
– ident: ref157/cit157
  doi: 10.3390/polym13020292
– ident: ref107/cit107
  doi: 10.3390/ma13245633
– ident: ref134/cit134
  doi: 10.1016/S0167-7799(00)89017-4
– ident: ref117/cit117
  doi: 10.3934/matersci.2018.4.559
– ident: ref80/cit80
  doi: 10.1007/s41745-021-00276-8
– ident: ref5/cit5
  doi: 10.1161/CIRCULATIONAHA.110.971606
– ident: ref149/cit149
  doi: 10.1016/j.colsurfa.2020.124555
– ident: ref71/cit71
  doi: 10.1016/j.ahj.2019.02.017
– ident: ref44/cit44
  doi: 10.1002/ccd.23397
– ident: ref108/cit108
  doi: 10.21037/jtd.2017.06.34
– ident: ref163/cit163
  doi: 10.3390/polym13081221
– ident: ref174/cit174
  doi: 10.1021/ma202270w
– ident: ref39/cit39
  doi: 10.1016/j.surfcoat.2021.127508
– ident: ref21/cit21
  doi: 10.1016/j.jvs.2012.12.069
– ident: ref114/cit114
  doi: 10.1111/aor.13851
– ident: ref43/cit43
  doi: 10.1007/s12928-016-0420-2
– ident: ref28/cit28
  doi: 10.1016/j.carrev.2018.11.006
– ident: ref147/cit147
  doi: 10.3390/molecules23040907
– ident: ref158/cit158
  doi: 10.1016/j.msec.2019.109950
– ident: ref36/cit36
  doi: 10.1016/j.ejpb.2019.12.017
– ident: ref141/cit141
  doi: 10.2147/IJN.S204221
– ident: ref64/cit64
  doi: 10.1158/1078-0432.CCR-19-2697
– ident: ref125/cit125
  doi: 10.1016/B978-0-12-817870-6.00004-3
– ident: ref144/cit144
  doi: 10.1016/S0142-9612(02)00233-8
– ident: ref74/cit74
  doi: 10.1016/j.bioactmat.2021.09.002
– ident: ref34/cit34
  doi: 10.1016/j.jvs.2008.10.016
– ident: ref42/cit42
  doi: 10.1155/2012/608593
– ident: ref22/cit22
  doi: 10.1016/j.ejpb.2020.12.005
– start-page: 161
  volume-title: 3D Printing and Biofabrication.
  year: 2018
  ident: ref31/cit31
  doi: 10.1007/978-3-319-45444-3_22
  contributor:
    fullname: Rodriguez C. A.
– ident: ref178/cit178
  doi: 10.1039/C8RA08541B
– ident: ref177/cit177
  doi: 10.2494/photopolymer.32.511
– ident: ref120/cit120
  doi: 10.1002/anie.201709934
– ident: ref156/cit156
  doi: 10.1016/j.polymdegradstab.2020.109254
– ident: ref133/cit133
  doi: 10.1021/la9905113
– ident: ref155/cit155
  doi: 10.1016/B978-0-08-100496-8.00007-X
– ident: ref20/cit20
  doi: 10.1161/CIRCINTERVENTIONS.110.959882
– ident: ref23/cit23
  doi: 10.1016/j.ijcard.2014.09.143
– ident: ref128/cit128
  doi: 10.15171/apb.2017.002
– ident: ref70/cit70
  doi: 10.1016/j.ijpharm.2013.07.003
– ident: ref111/cit111
  doi: 10.1016/j.msec.2014.12.049
– ident: ref46/cit46
  doi: 10.2165/00003088-200443020-00002
– ident: ref48/cit48
  doi: 10.5603/CJ.2017.0089
– ident: ref63/cit63
  doi: 10.1067/mcp.2001.112969
– ident: ref173/cit173
  doi: 10.1023/A:1008939400812
– ident: ref51/cit51
  doi: 10.1016/j.ihj.2016.10.008
– ident: ref85/cit85
  doi: 10.1002/jbm.b.31922
– ident: ref49/cit49
  doi: 10.1016/j.carrev.2018.04.022
– ident: ref1/cit1
  doi: 10.1016/S0140-6736(20)30925-9
– ident: ref35/cit35
  doi: 10.1016/S0002-9149(99)00484-1
– ident: ref168/cit168
  doi: 10.1063/5.0037298
– ident: ref84/cit84
  doi: 10.1002/adhm.201501019
– ident: ref112/cit112
  doi: 10.1023/A:1006808119862
– ident: ref45/cit45
  doi: 10.1016/j.jcin.2017.06.070
– ident: ref82/cit82
  doi: 10.3390/app9173527
– ident: ref68/cit68
  doi: 10.1002/app.50389
– ident: ref87/cit87
  doi: 10.1016/j.actbio.2009.10.006
– ident: ref60/cit60
  doi: 10.1016/S0041-1345(98)00588-0
– ident: ref33/cit33
  doi: 10.1080/136457002760273340
– ident: ref65/cit65
  doi: 10.1021/ie102163z
– ident: ref75/cit75
  doi: 10.1002/advs.201900856
– ident: ref55/cit55
  doi: 10.1080/17434440.2020.1747434
– ident: ref123/cit123
  doi: 10.1021/acsami.0c01444
– ident: ref122/cit122
  doi: 10.1021/acs.biomac.0c01082
– ident: ref37/cit37
  doi: 10.3390/app11041478
– ident: ref52/cit52
  doi: 10.6515/ACS20151013G
SSID ssj0002003189
Score 2.281461
SecondaryResourceType review_article
Snippet Globally, the leading causes of natural death are attributed to coronary heart disease and type 1 and type 2 diabetes. High blood pressure levels, high...
SourceID proquest
crossref
pubmed
acs
SourceType Aggregation Database
Index Database
Publisher
StartPage 4701
Title Drug-Eluting, Bioresorbable Cardiovascular StentsChallenges and Perspectives
URI http://dx.doi.org/10.1021/acsabm.2c00551
https://www.ncbi.nlm.nih.gov/pubmed/36150217
https://search.proquest.com/docview/2717689226
Volume 5
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3JTsMwELVQucCBfSmbgkDigktiO3F8hNKqQmKRAIlbZMc2QogUNemFH-FX-Cq-AU_ShYIquEeWNTPOvNneIHRoYb0e5QSLOJCYiUBhqYnAIU0NETpKYwMJ_curqHPPLh7Ch3G-42cFnwQnMs2lemmQFOiiXJwzS5xThDDrtHk7yqaQ0jgB6wKAxg5UkyFD468jwA-l-aQfmgIuSyfTXqwYj_KSmxB6S54b_UI10rffzI1_3n8JLQyQpndamcYymjHZCpr_xj-4iq7Pe_1H3ALjyx6PvbOnrgu-uz0F41Rec6JT1bstoOXi8_2jOVy_knsy097NeFozX0P37dZds4MHGxawpNQvsI6lCEXAtOE-435kqXTwKRJEWRFbxtyfUthY81hCQZOlFNjPeGhiLbSNbUTXUS3rZmYTeb6NtOU-l5qnjCkrQ2ul0kZpxoiWtI4OnCSSwQvJk7L4TYKkEk8yEE8dHQ21krxWdBtTv9wfKi1xLwLKHDIz3X6eOPtwMZRwuLKONiptjs6iwH_vorCtf91mG80RmHaABha-g2pFr292HQYp1F5pfl-1UdaE
link.rule.ids 315,786,790,2782,27107,27955,27956,57091,57141
linkProvider American Chemical Society
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3NTtwwEB4hOFAO_LRQlr-maqVe8JLYTmwfYWG15We7EiBxi-zYRhUiizbZCy_Cq_BUPAN2drOwRUj0GkWjiWec-cYz8xngp_XX6xGGkeCRRFRECkmNBYpJZrDQScaNP9A_6yadS3p8FV_NwF49C-OUKJykoiriv7ALRHvumVS3TZx51iiX7szFzIU6j4Va55NDFVz5qIe8Hkcjh61xTdT4RoQPR1kxHY7ewZhVrGkvQW-iZdVictMclqqZ3f9D4Pgfn7EMi2PcGeyPHGUFZkz-GRZesRF-gT-Hg-E1OvKumF_vBgd_-y4V7w-UH64KWlN9q8F56Rswnh4eW_VlLEUgcx30XmY3i1W4bB9dtDpofN8CkoSEJdJcilhEVBsWUhYmlkgHphKBlRXcUur-m8Jyzbj05U2aEc-FxmLDtdCW24SswWzez806BKFNtGUhk5pllCorY2ul0kZpSrGWpAE_3Eqk4_1SpFUpHEfpaHnS8fI04FdtnPRuRL7x7pvfa9ulbn_4oofMTX9YpNjlqwkXDmU24OvIqBNZxLPhu5xs40PafIP5zsXZaXr6u3uyCZ-wn4PwrS1sC2bLwdBsO3RSqp3KI58BK73e7w
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3bTuMwELVWIK3gAViuZWEJAokXXBLbie1HKFTcQQIk3iI7tiuESFGTvvAj_Mp-Fd-AJ03LZYW0vEaR5cwlPuOZOYPQpoPxepQTLEWkMJORxsoQiWOaWSJNkgkLF_pn58nhDTu-jW_rPm7ohfGbKPxKRZXEB69-NK5mGIh2_HOlH5okA-YoH_KMxzxi4I27ravRxQqp7BRgL2Bp7PE1GZI1_rMEHElZ8fFI-gJnVudNexpdj3ZalZncN_ulbmZPn0gcv_kpM2iqxp_B7sBgfqEfNp9Fk-9YCefQxX6v38EHYJJ5ZzvYu-v6kLzb09BkFbQ-1K8GVyUUYrw8_20Nh7IUgcpNcPnWw1nMo5v2wXXrENdzF7CiNCyxEUrGMmLG8pDxMHFUeVCVSKKdFI4x__-UThguFKQ5WUaBE43HVhhpnHAJXUBjeTe3SygIXWIcD7kyPGNMOxU7p7Sx2jBGjKINtOElkdZ-U6RVSpxE6UA8aS2eBtoaKih9HJBwfPnm-lB_qfcTSH6o3Hb7RUp83JoI6dFmAy0OFDtaiwIrvo_Nlv9rN2vo5-V-Oz09Oj_5jSYItENAhQtfQWNlr29XPUgp9Z_KKF8BYpDhaQ
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Drug-Eluting%2C+Bioresorbable+Cardiovascular+Stents%EE%97%B8Challenges+and+Perspectives&rft.jtitle=ACS+applied+bio+materials&rft.au=Vallejo-Zamora%2C+Julio+A.&rft.au=Vega-Cantu%2C+Yadira+I.&rft.au=Rodriguez%2C+Ciro&rft.au=Cordell%2C+Geoffrey+A.&rft.date=2022-10-17&rft.pub=American+Chemical+Society&rft.issn=2576-6422&rft.eissn=2576-6422&rft.volume=5&rft.issue=10&rft.spage=4701&rft.epage=4717&rft_id=info:doi/10.1021%2Facsabm.2c00551&rft.externalDocID=b363643040
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2576-6422&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2576-6422&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2576-6422&client=summon