Layered Double Hydroxide and Polypeptide Thermogel Nanocomposite System for Chondrogenic Differentiation of Stem Cells

• Published in: ACS applied materials & interfaces Vol. 9; no. 49; pp. 42668 - 42675
• Main Authors: Lee, Seon Sook, Choi, Go Eun, Lee, Hyun Jung, Kim, Yelin, Choy, Jin-Ho, Jeong, Byeongmoon
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 13.12.2017
• Subjects: Cell Differentiation; Cells, Cultured; Chondrocytes; Chondrogenesis; Hydroxides; Mesenchymal Stem Cells; Nanocomposites; Peptides; Stem Cells; Tissue Engineering; chondrogenic differentiation; layered double hydroxide (LDH); 3D culture; stem cell; sol−gel transition

Stem cell therapy for damaged cartilage suffers from low rates of retention, survival, and differentiation into chondrocytes at the target site. To solve these problems, here we propose a two-dimensional/three-dimensional (2D/3D) nanocomposite system. As a new two-dimensional (2D) material, hexagona...