SERS-Based Microfluidic Bioscreening Platform for Selective Detection of β‑Amyloid Peptides

• Published in: Langmuir Vol. 40; no. 46; pp. 24463 - 24470
• Main Authors: Jaiswal, Ankita, Mishra, Shubham, Dwivedi, Prabhat K., Verma, Sandeep
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 19.11.2024
• Subjects: cerebrospinal fluid; crosslinking; energy; ligands; nanosilver; peptides; polydimethylsiloxane; Raman spectroscopy

This study reports development of a microfluidic device for highly sensitive and selective detection of a β-amyloid peptide (Aβ1–42) in simulated cerebrospinal fluid, using surface-enhanced Raman spectroscopy (SERS). The device ensemble comprises a purine ligand (Pu) and its interaction with silver...