SERS-Based Microfluidic Bioscreening Platform for Selective Detection of β‑Amyloid Peptides
This study reports development of a microfluidic device for highly sensitive and selective detection of a β-amyloid peptide (Aβ1–42) in simulated cerebrospinal fluid, using surface-enhanced Raman spectroscopy (SERS). The device ensemble comprises a purine ligand (Pu) and its interaction with silver...
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| Published in | Langmuir Vol. 40; no. 46; pp. 24463 - 24470 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
American Chemical Society
19.11.2024
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| Subjects | |
| Online Access | Get full text |
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| Abstract | This study reports development of a microfluidic device for highly sensitive and selective detection of a β-amyloid peptide (Aβ1–42) in simulated cerebrospinal fluid, using surface-enhanced Raman spectroscopy (SERS). The device ensemble comprises a purine ligand (Pu) and its interaction with silver nanoparticles (AgNPs) to generate SERS hotspots. The low surface energy of the synthesized Pu ligand and high surface energy of AgNPs are utilized for the functionalization and formation of a Pu–AgNP SERS substrate. We have integrated a novel polydimethylsiloxane (PDMS) microfluidic device with Pu–AgNPs using a combination of photo- and soft lithography fabrication, sealed by thermal cross-linking with another layer of PDMS, to produce an effective screening platform for Aβ1–42. The SERS spectrum from the microfluidic device affords almost noise-free measurements, with excellent limit-of-detection values. |
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| AbstractList | This study reports development of a microfluidic device for highly sensitive and selective detection of a β-amyloid peptide (Aβ1-42) in simulated cerebrospinal fluid, using surface-enhanced Raman spectroscopy (SERS). The device ensemble comprises a purine ligand (Pu) and its interaction with silver nanoparticles (AgNPs) to generate SERS hotspots. The low surface energy of the synthesized Pu ligand and high surface energy of AgNPs are utilized for the functionalization and formation of a Pu-AgNP SERS substrate. We have integrated a novel polydimethylsiloxane (PDMS) microfluidic device with Pu-AgNPs using a combination of photo- and soft lithography fabrication, sealed by thermal cross-linking with another layer of PDMS, to produce an effective screening platform for Aβ1-42. The SERS spectrum from the microfluidic device affords almost noise-free measurements, with excellent limit-of-detection values.This study reports development of a microfluidic device for highly sensitive and selective detection of a β-amyloid peptide (Aβ1-42) in simulated cerebrospinal fluid, using surface-enhanced Raman spectroscopy (SERS). The device ensemble comprises a purine ligand (Pu) and its interaction with silver nanoparticles (AgNPs) to generate SERS hotspots. The low surface energy of the synthesized Pu ligand and high surface energy of AgNPs are utilized for the functionalization and formation of a Pu-AgNP SERS substrate. We have integrated a novel polydimethylsiloxane (PDMS) microfluidic device with Pu-AgNPs using a combination of photo- and soft lithography fabrication, sealed by thermal cross-linking with another layer of PDMS, to produce an effective screening platform for Aβ1-42. The SERS spectrum from the microfluidic device affords almost noise-free measurements, with excellent limit-of-detection values. This study reports development of a microfluidic device for highly sensitive and selective detection of a β-amyloid peptide (Aβ₁–₄₂) in simulated cerebrospinal fluid, using surface-enhanced Raman spectroscopy (SERS). The device ensemble comprises a purine ligand (Pu) and its interaction with silver nanoparticles (AgNPs) to generate SERS hotspots. The low surface energy of the synthesized Pu ligand and high surface energy of AgNPs are utilized for the functionalization and formation of a Pu–AgNP SERS substrate. We have integrated a novel polydimethylsiloxane (PDMS) microfluidic device with Pu–AgNPs using a combination of photo- and soft lithography fabrication, sealed by thermal cross-linking with another layer of PDMS, to produce an effective screening platform for Aβ₁–₄₂. The SERS spectrum from the microfluidic device affords almost noise-free measurements, with excellent limit-of-detection values. This study reports development of a microfluidic device for highly sensitive and selective detection of a β-amyloid peptide (Aβ ) in simulated cerebrospinal fluid, using surface-enhanced Raman spectroscopy (SERS). The device ensemble comprises a purine ligand (Pu) and its interaction with silver nanoparticles (AgNPs) to generate SERS hotspots. The low surface energy of the synthesized Pu ligand and high surface energy of AgNPs are utilized for the functionalization and formation of a Pu-AgNP SERS substrate. We have integrated a novel polydimethylsiloxane (PDMS) microfluidic device with Pu-AgNPs using a combination of photo- and soft lithography fabrication, sealed by thermal cross-linking with another layer of PDMS, to produce an effective screening platform for Aβ . The SERS spectrum from the microfluidic device affords almost noise-free measurements, with excellent limit-of-detection values. This study reports development of a microfluidic device for highly sensitive and selective detection of a β-amyloid peptide (Aβ1–42) in simulated cerebrospinal fluid, using surface-enhanced Raman spectroscopy (SERS). The device ensemble comprises a purine ligand (Pu) and its interaction with silver nanoparticles (AgNPs) to generate SERS hotspots. The low surface energy of the synthesized Pu ligand and high surface energy of AgNPs are utilized for the functionalization and formation of a Pu–AgNP SERS substrate. We have integrated a novel polydimethylsiloxane (PDMS) microfluidic device with Pu–AgNPs using a combination of photo- and soft lithography fabrication, sealed by thermal cross-linking with another layer of PDMS, to produce an effective screening platform for Aβ1–42. The SERS spectrum from the microfluidic device affords almost noise-free measurements, with excellent limit-of-detection values. |
| Author | Dwivedi, Prabhat K. Verma, Sandeep Mishra, Shubham Jaiswal, Ankita |
| AuthorAffiliation | Department of Chemistry, Center for Environmental Sciences and Engineering, Center for Nanosciences, and Mehta Family Center for Engineering in Medicine Indian Institute of Technology Kanpur Center for Nanosciences |
| AuthorAffiliation_xml | – name: Center for Nanosciences – name: Department of Chemistry, Center for Environmental Sciences and Engineering, Center for Nanosciences, and Mehta Family Center for Engineering in Medicine – name: Indian Institute of Technology Kanpur |
| Author_xml | – sequence: 1 givenname: Ankita surname: Jaiswal fullname: Jaiswal, Ankita organization: Department of Chemistry, Center for Environmental Sciences and Engineering, Center for Nanosciences, and Mehta Family Center for Engineering in Medicine – sequence: 2 givenname: Shubham surname: Mishra fullname: Mishra, Shubham organization: Indian Institute of Technology Kanpur – sequence: 3 givenname: Prabhat K. orcidid: 0000-0003-0248-1461 surname: Dwivedi fullname: Dwivedi, Prabhat K. email: prabhatd@iitk.ac.in organization: Indian Institute of Technology Kanpur – sequence: 4 givenname: Sandeep orcidid: 0000-0002-2478-8109 surname: Verma fullname: Verma, Sandeep email: sverma@iitk.ac.in organization: Department of Chemistry, Center for Environmental Sciences and Engineering, Center for Nanosciences, and Mehta Family Center for Engineering in Medicine |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/39514697$$D View this record in MEDLINE/PubMed |
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| Snippet | This study reports development of a microfluidic device for highly sensitive and selective detection of a β-amyloid peptide (Aβ1–42) in simulated cerebrospinal... This study reports development of a microfluidic device for highly sensitive and selective detection of a β-amyloid peptide (Aβ ) in simulated cerebrospinal... This study reports development of a microfluidic device for highly sensitive and selective detection of a β-amyloid peptide (Aβ1-42) in simulated cerebrospinal... This study reports development of a microfluidic device for highly sensitive and selective detection of a β-amyloid peptide (Aβ₁–₄₂) in simulated cerebrospinal... |
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| SubjectTerms | cerebrospinal fluid crosslinking energy ligands nanosilver peptides polydimethylsiloxane Raman spectroscopy |
| Title | SERS-Based Microfluidic Bioscreening Platform for Selective Detection of β‑Amyloid Peptides |
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