A facile synthesis of N-protected statine and analogs via a lipase-catalyzed kinetic resolution
A new synthesis of N-protected statine 4a and its analogue 4b is presented. cis-(+/-)-Butyric acid 2-isobutyl-5-oxopyrrolidin-3-yl ester (10a) and cis-(+/-)-butyric acid 2-benzyl-5-oxopyrrolidin-3-yl ester (10b) were prepared from methyl (E)-4-chloro-3-methoxybut-2-enoate (5) and subsequently resolv...
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Published in | Journal of organic chemistry Vol. 58; no. 15; pp. 4010 - 4012 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
WASHINGTON
American Chemical Society
01.07.1993
Amer Chemical Soc |
Subjects | |
Online Access | Get full text |
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