Tandem Azolation/Aromatization of Tetrahydronaphthalenes with Hydrogen Evolution via Organophotoredox/Cobalt Dual Catalysis

• Published in: Organic letters Vol. 27; no. 13; pp. 3284 - 3290
• Main Authors: Huang, Cheng, Tang, Sheng, Wang, Chen-Lu, Kang, Chen, Wang, Ying, Jing, Yaru, Ye, Zhong-Ming, Wei, Zhenhong, Cai, Hu
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 04.04.2025
• Subjects: aromatization; catalytic activity; cobalt; cross-coupling reactions; dehydrogenation; hydrogen production; irradiation; light; redox reactions; tetrahydronaphthalenes

Reported herein is a photoredox/cobaloxime dual-catalytic approach to execute tandem dehydrogenative azolation and aromatization of tetrahydronaphthalene for rapid construction of N-(β-naphthyl)­azole architectures. This protocol highlights noble metal-free and external oxidants-free conditions, ste...