Platelet Membrane-Coated HGF-PLGA Nanoparticles Promote Therapeutic Angiogenesis and Tissue Perfusion Recovery in Ischemic Hindlimbs

• Published in: ACS applied bio materials Vol. 8; no. 1; pp. 399 - 409
• Main Authors: Wang, Peng, Di, Xiao, Li, Fengshi, Rong, Zhihua, Lian, Wenzhuo, Li, Zongshu, Chen, Tianqi, Wang, Wenjing, Zhong, Qing, Sun, Guoqiang, Ni, Leng, Liu, ChangWei
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 20.01.2025
• Subjects: Angiogenesis; Animals; Biocompatible Materials - chemistry; Biocompatible Materials - pharmacology; Blood Platelets - chemistry; Cell Movement - drug effects; Cell Proliferation - drug effects; Hepatocyte Growth Factor - chemistry; Hepatocyte Growth Factor - pharmacology; Hindlimb - blood supply; Hindlimb - drug effects; Humans; Ischemia - drug therapy; Male; Materials Testing; Nanoparticles - chemistry; Neovascularization, Physiologic - drug effects; Particle Size; Polylactic Acid-Polyglycolic Acid Copolymer - chemistry; Polylactic Acid-Polyglycolic Acid Copolymer - pharmacology; Rats; Rats, Sprague-Dawley; Surface Properties; therapeutic angiogenesis; peripheral artery disease; drug delivery; chronic limb-threatening ischemia; hepatocyte growth factor

Therapeutic angiogenesis has garnered significant attention as a potential treatment strategy for lower limb ischemic diseases. Although hepatocyte growth factor (HGF) has been identified as a key promoter of therapeutic angiogenesis, its clinical application is limited due to its short half-life. I...