Platelet Membrane-Coated HGF-PLGA Nanoparticles Promote Therapeutic Angiogenesis and Tissue Perfusion Recovery in Ischemic Hindlimbs

Therapeutic angiogenesis has garnered significant attention as a potential treatment strategy for lower limb ischemic diseases. Although hepatocyte growth factor (HGF) has been identified as a key promoter of therapeutic angiogenesis, its clinical application is limited due to its short half-life. I...

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Published inACS applied bio materials Vol. 8; no. 1; pp. 399 - 409
Main Authors Wang, Peng, Di, Xiao, Li, Fengshi, Rong, Zhihua, Lian, Wenzhuo, Li, Zongshu, Chen, Tianqi, Wang, Wenjing, Zhong, Qing, Sun, Guoqiang, Ni, Leng, Liu, ChangWei
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 20.01.2025
Subjects
Angiogenesis
Animals
Biocompatible Materials - chemistry
Biocompatible Materials - pharmacology
Blood Platelets - chemistry
Cell Movement - drug effects
Cell Proliferation - drug effects
Hepatocyte Growth Factor - chemistry
Hepatocyte Growth Factor - pharmacology
Hindlimb - blood supply
Hindlimb - drug effects
Humans
Ischemia - drug therapy
Male
Materials Testing
Nanoparticles - chemistry
Neovascularization, Physiologic - drug effects
Particle Size
Polylactic Acid-Polyglycolic Acid Copolymer - chemistry
Polylactic Acid-Polyglycolic Acid Copolymer - pharmacology
Rats
Rats, Sprague-Dawley
Surface Properties
therapeutic angiogenesis
peripheral artery disease
drug delivery
chronic limb-threatening ischemia
hepatocyte growth factor
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Abstract Therapeutic angiogenesis has garnered significant attention as a potential treatment strategy for lower limb ischemic diseases. Although hepatocyte growth factor (HGF) has been identified as a key promoter of therapeutic angiogenesis, its clinical application is limited due to its short half-life. In this study, we successfully developed and characterized platelet membrane-coated HGF-poly­(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs). These nanoparticles demonstrated enhanced capabilities to promote endothelial cell (EC) proliferation, migration, and tube formation in vitro. Additionally, their efficacy in improving tissue perfusion and promoting angiogenesis was confirmed in a hindlimb ischemia rat model. Our findings suggest that platelet membrane-coated HGF-PLGA-NPs could serve as a promising therapeutic approach for enhancing angiogenesis and restoring tissue perfusion in ischemic conditions.
AbstractList Therapeutic angiogenesis has garnered significant attention as a potential treatment strategy for lower limb ischemic diseases. Although hepatocyte growth factor (HGF) has been identified as a key promoter of therapeutic angiogenesis, its clinical application is limited due to its short half-life. In this study, we successfully developed and characterized platelet membrane-coated HGF-poly(lactic- -glycolic acid) (PLGA) nanoparticles (NPs). These nanoparticles demonstrated enhanced capabilities to promote endothelial cell (EC) proliferation, migration, and tube formation in vitro. Additionally, their efficacy in improving tissue perfusion and promoting angiogenesis was confirmed in a hindlimb ischemia rat model. Our findings suggest that platelet membrane-coated HGF-PLGA-NPs could serve as a promising therapeutic approach for enhancing angiogenesis and restoring tissue perfusion in ischemic conditions.
Therapeutic angiogenesis has garnered significant attention as a potential treatment strategy for lower limb ischemic diseases. Although hepatocyte growth factor (HGF) has been identified as a key promoter of therapeutic angiogenesis, its clinical application is limited due to its short half-life. In this study, we successfully developed and characterized platelet membrane-coated HGF-poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs). These nanoparticles demonstrated enhanced capabilities to promote endothelial cell (EC) proliferation, migration, and tube formation in vitro. Additionally, their efficacy in improving tissue perfusion and promoting angiogenesis was confirmed in a hindlimb ischemia rat model. Our findings suggest that platelet membrane-coated HGF-PLGA-NPs could serve as a promising therapeutic approach for enhancing angiogenesis and restoring tissue perfusion in ischemic conditions.Therapeutic angiogenesis has garnered significant attention as a potential treatment strategy for lower limb ischemic diseases. Although hepatocyte growth factor (HGF) has been identified as a key promoter of therapeutic angiogenesis, its clinical application is limited due to its short half-life. In this study, we successfully developed and characterized platelet membrane-coated HGF-poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs). These nanoparticles demonstrated enhanced capabilities to promote endothelial cell (EC) proliferation, migration, and tube formation in vitro. Additionally, their efficacy in improving tissue perfusion and promoting angiogenesis was confirmed in a hindlimb ischemia rat model. Our findings suggest that platelet membrane-coated HGF-PLGA-NPs could serve as a promising therapeutic approach for enhancing angiogenesis and restoring tissue perfusion in ischemic conditions.
Therapeutic angiogenesis has garnered significant attention as a potential treatment strategy for lower limb ischemic diseases. Although hepatocyte growth factor (HGF) has been identified as a key promoter of therapeutic angiogenesis, its clinical application is limited due to its short half-life. In this study, we successfully developed and characterized platelet membrane-coated HGF-poly­(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs). These nanoparticles demonstrated enhanced capabilities to promote endothelial cell (EC) proliferation, migration, and tube formation in vitro. Additionally, their efficacy in improving tissue perfusion and promoting angiogenesis was confirmed in a hindlimb ischemia rat model. Our findings suggest that platelet membrane-coated HGF-PLGA-NPs could serve as a promising therapeutic approach for enhancing angiogenesis and restoring tissue perfusion in ischemic conditions.
Author Wang, Peng
Li, Fengshi
Rong, Zhihua
Liu, ChangWei
Chen, Tianqi
Zhong, Qing
Di, Xiao
Li, Zongshu
Ni, Leng
Wang, Wenjing
Lian, Wenzhuo
Sun, Guoqiang
AuthorAffiliation Department of Vascular Surgery
Biomedical Engineering Facility of National Infrastructures for Translational Medicine, Institute of Clinical Medicine
Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College
Laboratory Animal Research Facility, National Infrastructures for Translational Medicine, Institute of Clinical Medicine
Department of Information Center
Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
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Cites_doi 10.1002/adma.201706759
10.1038/gt.2010.101
10.1016/j.ahj.2022.08.007
10.1016/j.biomaterials.2017.02.041
10.1039/D0NR08492A
10.1038/mt.2008.33
10.1016/S0140-6736(96)03361-2
10.1002/sstr.202000018
10.1371/journal.pone.0038776
10.1186/s13073-023-01250-y
10.1172/JCI113334
10.1093/oxfordjournals.jbchem.a021283
10.1007/s13346-024-01577-y
10.1016/j.jconrel.2020.08.030
10.1161/01.ATV.0000048701.86621.D0
10.1016/j.nano.2018.08.002
10.1111/j.1440-1746.2010.06549.x
10.1016/j.vph.2012.02.002
10.2183/pjab.86.588
10.3389/fimmu.2020.02135
10.1016/j.jvs.2019.02.016
10.1093/eurheartj/ehx095
10.1089/hum.2017.217
10.1016/j.jacc.2018.03.008
10.2147/IJN.S452989
10.1039/D0NR08440A
10.1021/acsnano.7b07720
10.2147/IJN.S214727
10.3389/fendo.2020.00062
10.1186/1479-5876-9-55
10.1021/acsami.3c18464
10.1038/nature15373
10.2147/IJN.S423186
10.1016/j.isci.2022.105147
10.1016/j.apsb.2017.12.002
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Keywords therapeutic angiogenesis
peripheral artery disease
drug delivery
chronic limb-threatening ischemia
hepatocyte growth factor
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References ref9/cit9
ref6/cit6
ref3/cit3
ref27/cit27
ref18/cit18
ref11/cit11
ref25/cit25
ref16/cit16
ref29/cit29
ref32/cit32
ref23/cit23
ref14/cit14
ref8/cit8
ref5/cit5
ref31/cit31
ref2/cit2
ref34/cit34
ref28/cit28
ref20/cit20
ref17/cit17
ref10/cit10
ref26/cit26
ref35/cit35
ref19/cit19
ref21/cit21
ref12/cit12
ref15/cit15
ref22/cit22
ref13/cit13
ref33/cit33
ref4/cit4
ref30/cit30
ref1/cit1
ref24/cit24
ref7/cit7
References_xml – ident: ref16/cit16
  doi: 10.1002/adma.201706759
– ident: ref5/cit5
  doi: 10.1038/gt.2010.101
– ident: ref6/cit6
  doi: 10.1016/j.ahj.2022.08.007
– ident: ref17/cit17
  doi: 10.1016/j.biomaterials.2017.02.041
– ident: ref18/cit18
  doi: 10.1039/D0NR08492A
– ident: ref7/cit7
  doi: 10.1038/mt.2008.33
– ident: ref4/cit4
  doi: 10.1016/S0140-6736(96)03361-2
– ident: ref20/cit20
  doi: 10.1002/sstr.202000018
– ident: ref35/cit35
  doi: 10.1371/journal.pone.0038776
– ident: ref28/cit28
  doi: 10.1186/s13073-023-01250-y
– ident: ref32/cit32
  doi: 10.1172/JCI113334
– ident: ref31/cit31
  doi: 10.1093/oxfordjournals.jbchem.a021283
– ident: ref13/cit13
  doi: 10.1007/s13346-024-01577-y
– ident: ref26/cit26
  doi: 10.1016/j.jconrel.2020.08.030
– ident: ref9/cit9
  doi: 10.1161/01.ATV.0000048701.86621.D0
– ident: ref34/cit34
  doi: 10.1016/j.nano.2018.08.002
– ident: ref33/cit33
  doi: 10.1111/j.1440-1746.2010.06549.x
– ident: ref12/cit12
  doi: 10.1016/j.vph.2012.02.002
– ident: ref11/cit11
  doi: 10.2183/pjab.86.588
– ident: ref10/cit10
  doi: 10.3389/fimmu.2020.02135
– ident: ref2/cit2
  doi: 10.1016/j.jvs.2019.02.016
– ident: ref1/cit1
  doi: 10.1093/eurheartj/ehx095
– ident: ref8/cit8
  doi: 10.1089/hum.2017.217
– ident: ref3/cit3
  doi: 10.1016/j.jacc.2018.03.008
– ident: ref15/cit15
  doi: 10.2147/IJN.S452989
– ident: ref19/cit19
  doi: 10.1039/D0NR08440A
– ident: ref25/cit25
  doi: 10.1021/acsnano.7b07720
– ident: ref22/cit22
  doi: 10.2147/IJN.S214727
– ident: ref29/cit29
  doi: 10.3389/fendo.2020.00062
– ident: ref30/cit30
  doi: 10.1186/1479-5876-9-55
– ident: ref14/cit14
  doi: 10.1021/acsami.3c18464
– ident: ref21/cit21
  doi: 10.1038/nature15373
– ident: ref24/cit24
  doi: 10.2147/IJN.S423186
– ident: ref23/cit23
  doi: 10.1016/j.isci.2022.105147
– ident: ref27/cit27
  doi: 10.1016/j.apsb.2017.12.002
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Snippet Therapeutic angiogenesis has garnered significant attention as a potential treatment strategy for lower limb ischemic diseases. Although hepatocyte growth...
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SubjectTerms Angiogenesis
Animals
Biocompatible Materials - chemistry
Biocompatible Materials - pharmacology
Blood Platelets - chemistry
Cell Movement - drug effects
Cell Proliferation - drug effects
Hepatocyte Growth Factor - chemistry
Hepatocyte Growth Factor - pharmacology
Hindlimb - blood supply
Hindlimb - drug effects
Humans
Ischemia - drug therapy
Male
Materials Testing
Nanoparticles - chemistry
Neovascularization, Physiologic - drug effects
Particle Size
Polylactic Acid-Polyglycolic Acid Copolymer - chemistry
Polylactic Acid-Polyglycolic Acid Copolymer - pharmacology
Rats
Rats, Sprague-Dawley
Surface Properties
Title Platelet Membrane-Coated HGF-PLGA Nanoparticles Promote Therapeutic Angiogenesis and Tissue Perfusion Recovery in Ischemic Hindlimbs
URI http://dx.doi.org/10.1021/acsabm.4c01373
https://www.ncbi.nlm.nih.gov/pubmed/39723905
https://www.proquest.com/docview/3149540551
Volume 8
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